Skip to main content

Advertisement

Log in

Understanding the Haldane effect

  • Understanding the Disease
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Christiansen J, Douglas CG, Haldane JS (1914) The absorption and dissociation of carbon dioxide by human blood. J Physiol 48:244–271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zhang H, Vincent JL (1993) Arteriovenous differences in PCO2 and pH are good indicators of critical hypoperfusion. Am Rev Respir Dis 148:867–871

    Article  CAS  PubMed  Google Scholar 

  3. Dres M, Monnet X, Teboul JL (2012) Hemodynamic management of cardiovascular failure by using PCO(2) venous-arterial difference. J Clin Monit Comput 26:367–374

    Article  PubMed  Google Scholar 

  4. Bakker J, Vincent JL, Gris P, Leon M, Coffernils M, Kahn RJ (1992) Veno-arterial carbon dioxide gradient in human septic shock. Chest 101:509–515

    Article  CAS  PubMed  Google Scholar 

  5. Mekontso-Dessap A, Castelain V, Anguel N, Bahloul M, Schauvliege F, Richard C, Teboul JL (2002) Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients. Intensive Care Med 28:272–277

    Article  PubMed  Google Scholar 

  6. Vallet B, Teboul JL, Cain S, Curtis S (2000) Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 89:1317–1321

    CAS  PubMed  Google Scholar 

  7. Jakob SM, Groeneveld ABJ, Teboul JL (2015) Venous–arterial CO2 to arterial–venous O2 difference ratio as a resuscitation target in shock states? Intensive Care Med 41:936–938

    Article  PubMed  Google Scholar 

  8. Giovannini I, Chiarla C, Boldrini G, Castagneto M (1993) Calculation of venoarterial CO2 concentration difference. J Appl Physiol 74:959–964

    CAS  PubMed  Google Scholar 

  9. Mallat J, Benzidi Y, Salleron J, Lemyze M, Gasan G, Vangrunderbeeck N, Pepy F, Tronchon L, Vallet B, Thevenin D (2014) Time course of central venous-to-arterial carbon dioxide tension difference in septic shock patients receiving incremental doses of dobutamine. Intensive Care Med 40:404–411

    Article  CAS  PubMed  Google Scholar 

  10. Ospina-Tascón GA, Umaña M, Bermúdez WF, Bautista-Rincón DF, Valencia JD, Madriñán HJ, Hernandez G, Bruhn A, Arango-Dávila C, De Backer D (2016) Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med 42:211–221

    Article  PubMed  Google Scholar 

  11. Ospina-Tascon GA, Bautista-Rincon DF, Umana M, Tafur JD, Gutierrez A, Garcia AF, Bermudez W, Granados M, Arango-Davila C, Hernandez G (2013) Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock. Crit Care 17:R294

    Article  PubMed  PubMed Central  Google Scholar 

  12. Vallee F, Vallet B, Mathe O, Parraguette J, Mari A, Silva S, Samii K, Fourcade O, Genestal M (2008) Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock? Intensive Care Med 34:2218–2225

    Article  PubMed  Google Scholar 

  13. Citerio G, Bakker J, Bassetti M, Benoit D, Cecconi M, Curtis JR, Doig GS, Herridge M, Jaber S, Joannidis M, Papazian L, Perner A, Peters MJ, Singer P, Smith M, Soares M, Torres A, Vieillard-Baron A, Timsit JF, Azoulay E (2015) Year in review in Intensive Care Medicine 2014: I. Cardiac dysfunction and cardiac arrest, ultrasound, neurocritical care, ICU-acquired weakness, nutrition, acute kidney injury, and miscellaneous. Intensive Care Med 41:179–191

    Article  PubMed Central  Google Scholar 

  14. Vallet B, Pinsky MR, Cecconi M (2013) Resuscitation of patients with septic shock: please “mind the gap”! Intensive Care Med 39:1653–1655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Monnet X, Julien F, Ait-Hamou N, Lequoy M, Gosset C, Jozwiak M, Persichini R, Anguel N, Richard C, Teboul JL (2013) Lactate and veno-arterial carbon dioxide difference/arterial-venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders. Crit Care Med 41:1412–1420

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jean-Louis Teboul.

Ethics declarations

Conflicts of interest

The authors have no conflict of interest to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Teboul, JL., Scheeren, T. Understanding the Haldane effect. Intensive Care Med 43, 91–93 (2017). https://doi.org/10.1007/s00134-016-4261-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-016-4261-3

Keywords

Navigation