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Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data

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Abstract

Clerodendrum viscosum Vent. is used in different indigenous systems of medicine by Asian ethnic communities. Significant advances in the validation of ethnomedicinal claims of C. viscosum are driving unprecedented opportunities for plant-based therapeutics leads and utilization of secondary metabolites for the mode of action studies. This study covered an updated and comprehensive review of the medicinal uses in traditional medicines, pharmacology, phytochemistry, and safety of C. viscosum. Extracts and phytoconstituents of C. viscosum have demonstrated a wide range of pharmacological effects such as anti-inflammatory, antioxidant, antidiabetic, anticancer, immunomodulatory, antibacterial, and hepatoprotection. More than 50 phytochemicals, representing the diverse classes of secondary metabolites that comprise both physiological and phytopharmaceutical significance, have been reported from C. viscosum. The molecules with terpenoids, flavonoids, steroids, and the glycosylated chemical scaffold and biological activities have demand in the pharmaceutical industry. An overview of the mechanism of action of prominent compounds has also been collated for future research on C. viscosum-based therapeutics.

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Acknowledgements

We are grateful to the Director, Central Institute of Medicinal and Aromatic Plants, Lucknow, for providing basic facilities for carrying out the work. Thanks to the Indian Council of Medical Research (ICMR), New Delhi, for the Senior Research Fellowship (No. 45/35/2018/TM/BMS) awarded to Madhumita Srivastava.

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  1. Analytical Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, 226015, India

    Madhumita Srivastava, Priyanka Maurya,  Jyotshna & Karuna Shanker

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, 201002, India

    Madhumita Srivastava, Priyanka Maurya & Karuna Shanker

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  1. Madhumita Srivastava
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  2. Priyanka Maurya
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  3. Jyotshna
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Data collection: PM; manuscript designing: Jyotshna; conceptualization, manuscript preparation, and interpretation: MS; critical revision: KS.

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Correspondence to Karuna Shanker.

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Srivastava, M., Maurya, P., Jyotshna et al. Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data. Med Chem Res 30, 2145–2167 (2021). https://doi.org/10.1007/s00044-021-02804-8

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