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Serendipitous formation of novel class of dichromeno pyrano pyrimidinone derivatives possessing anti-tubercular activity against M. tuberculosis H37Rv

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Abstract

One pot three-component reaction of salicylaldehyde, barbituric acid, and 4-OH coumarin catalyzed by ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY]+ [AlCl4]− in water resulted into unexpected formation of a novel class of dichromeno pyrano pyrimidinone derivatives. Synthesized compounds exhibited excellent in vitro anti-tubercular activity against M. tuberculosis H37Rv.

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Acknowledgements

One of the authors NCD is grateful to the University Grants Commission (UGC), New Delhi for providing financial assistance in the form of UGC-BSR-SAP fellowship (F.25–1/2014-15(BSR)/7-183/2009(BSR)–5 November 2015).

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Authors and Affiliations

  1. Department of Chemistry, Shivaji University, Kolhapur, Maharashtra, 416004, India

    Nilam C. Dige, Prasad G. Mahajan & Dattaprasad M. Pore

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  1. Nilam C. Dige
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  2. Prasad G. Mahajan
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  3. Dattaprasad M. Pore
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Correspondence to Dattaprasad M. Pore.

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Dige, N.C., Mahajan, P.G. & Pore, D.M. Serendipitous formation of novel class of dichromeno pyrano pyrimidinone derivatives possessing anti-tubercular activity against M. tuberculosis H37Rv. Med Chem Res 27, 224–233 (2018). https://doi.org/10.1007/s00044-017-2062-z

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