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Synthesis of substituted benzo[d]thiazol-2-ylcarbamates as potential anticonvulsants

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Abstract

A series of substituted benzo[d]thiazol-2-ylcarbamates 4a–g and 5a–g were synthesized and evaluated for anticonvulsant activity. The structures of the synthesized compounds were confirmed on the basis of their physical and spectral data. The compounds were evaluated for anticonvulsant activity using PTZ-induced convulsion and maximal electroshock models. The target compounds have shown significant activity in these models.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, P.D.E.A’S Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, 412301, India

    Ashvini Navale, Smita Pawar, Meenakshi Deodhar & Amol Kale

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  1. Ashvini Navale
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  2. Smita Pawar
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  3. Meenakshi Deodhar
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  4. Amol Kale
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Correspondence to Smita Pawar.

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Navale, A., Pawar, S., Deodhar, M. et al. Synthesis of substituted benzo[d]thiazol-2-ylcarbamates as potential anticonvulsants. Med Chem Res 22, 4316–4321 (2013). https://doi.org/10.1007/s00044-012-0434-y

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  • DOI: https://doi.org/10.1007/s00044-012-0434-y

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