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Overview on Biological Activities of Pyrazole Derivatives

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Nanostructured Biomaterials

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

Pyrazoles are appraised as medicinally significant heterocyclic nuclei that exhibit a widespread spectrum of biological properties. The existence of pyrazole derivatives as pharmacophore in distinct remedial divisions like the antipsychotic CDPPB, an effective anti-inflammatory, celecoxib; difenamizole, an analgesic, rimonabant; the anti-obesity drug, the antidepressant agent fezolamide and betazole, a H2-receptor agonist have ascertained medicinal potentiality of this scaffold. In this regard, pyrazole, one of the most powerful pharmacophores, has been an important topic of research for the scientist around the globe. This chapter draws special attention to the various pharmacological and biological potentiality as well several studies on the pharmacological potency of pyrazole scaffolds emerged by various research groups all over the world are described.

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Abbreviations

US FDA:

United States Food and Drug Administration

ZE:

Zollinger–Ellison syndrome

ARB:

Angiotensin II receptor blocker

DNA:

Deoxyribonucleic acid

CNS:

Central nervous system

COX:

Cyclooxygenase

GABA:

Gamma-aminobutyric acid

NSAID:

Non-steroidal anti-inflammatory drugs

ADP:

Adenosine diphosphate

JAK:

Janus kinase

PARP:

Poly(ADP-ribose)polymerase

RNA:

Ribonucleic acid

HCV:

Hepatitis C virus

FGFR:

Fibroblast growth factor receptor

NRS:

Nuclear hormone receptors

MRSA:

Methicillin-resistant staphylococcus aureus

PRSA:

Penicillin-resistant S aureus

VRE:

Vancomycin-resistant enterococcus

HepG2:

Human liver cancer cell line

GIP:

Gastric inhibitory polypeptide

BGC823:

Human gastric carcinoma cell line

BT474:

Human breast tumour cell line

VEGF:

Vascular endothelial growth factor

RT-PCR:

Reverse transcription-polymerase chain reaction

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal, Manipur, 795004, India

    Arup K. Kabi, Raghuram Gujjarappa, Nagaraju Vodnala, Ujjawal Tyagi, Dhananjaya Kaldhi & Chandi C. Malakar

  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Chunilal Bhawan, 168, Maniktala Main Road, Kolkata, 700054, India

    Sattu Sravani, Aakriti Garg & Sreya Gupta

  3. Department of Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab, 151001, India

    Virender Singh

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    Bibhu Prasad Swain

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Kabi, A.K. et al. (2022). Overview on Biological Activities of Pyrazole Derivatives. In: Swain, B.P. (eds) Nanostructured Biomaterials. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-8399-2_7

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