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TUSC3: functional duality of a cancer gene

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Abstract

Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum.

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Authors and Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 126/3, 625 00, Brno, Czech Republic

    Kateřina Vašíčková & Petr Vaňhara

  2. International Clinical Research Center, St. Anne’s University Hospital Brno, Pekařská 53, 65691, Brno, Czech Republic

    Kateřina Vašíčková & Petr Vaňhara

  3. Department of Translational Oncology, National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Peter Horak

  4. German Cancer Research Center (DKFZ), Heidelberg, Germany

    Peter Horak

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  1. Kateřina Vašíčková
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KV drafted the manuscript, PH and PV conceptualized, wrote and revised the manuscript.

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Correspondence to Petr Vaňhara.

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Grant Agency of Masaryk University (MUNI/A/1369/2016), European Regional Development Fund (Center for Analysis and Modeling of Tissues and Organs, CZ.1.07/2.3.00/20.0185), the National Program of Sustainability II (Project no. LQ1605, MEYS CR).

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Vašíčková, K., Horak, P. & Vaňhara, P. TUSC3: functional duality of a cancer gene. Cell. Mol. Life Sci. 75, 849–857 (2018). https://doi.org/10.1007/s00018-017-2660-4

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