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The multifaceted role of periostin in priming the tumor microenvironments for tumor progression

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Abstract

Tumor microenvironment consists of tumor cells, stromal cells, extracellular matrix and a plethora of soluble components. The complex array of interactions between tumor cells and their surrounding tumor microenvironments contribute to the determination of the fate of tumor cells during tumorigenesis and metastasis. Matricellular protein periostin is generally absent in most adult tissues but is highly expressed in tumor microenvironments. Current evidence reveals that periostin plays a critical role in establishing and remodeling tumor microenvironments such as the metastatic niche, cancer stem cell niche, perivascular niche, pre-metastatic niche, fibrotic microenvironment and bone marrow microenvironment. Here, we summarize the current knowledge of the multifaceted role of periostin in the tumor microenvironments.

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Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (Nos. 81572598, 81372841), the Science and Technology Project of Natural Science Foundation of Fujian Province (No. 2016J01639), the Medical Innovations Topic in Fujian Province (No. 2016-CXB-8) and the Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University (SKLCSB2017KF007).

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Author notes

  1. Dan Cui, Zhengjie Huang and Yingfu Liu contributed equally to this work.

Authors and Affiliations

  1. First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China

    Dan Cui & Zhengjie Huang

  2. Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China

    Yingfu Liu

  3. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, 361102, China

    Gaoliang Ouyang

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  1. Dan Cui
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Correspondence to Gaoliang Ouyang.

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Cui, D., Huang, Z., Liu, Y. et al. The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cell. Mol. Life Sci. 74, 4287–4291 (2017). https://doi.org/10.1007/s00018-017-2646-2

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  • DOI: https://doi.org/10.1007/s00018-017-2646-2

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