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The Multiaspect Functions of Periostin in Tumor Progression

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Periostin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1132))

Abstract

Extracellular matrix protein periostin is highly expressed in various tumors and plays a critical role in tumor development and progression. Periostin is mainly secreted by stromal cells such as cancer-associated fibroblasts, myofibroblasts, osteoblasts and bone marrow-derived mesenchymal stromal cells. But in some cases, tumor cells, especially cancer stem cells, can also produce periostin. Periostin has been shown to regulate multiple biological behaviors of tumor cells, including proliferation, survival, invasion, angiogenesis, metastasis and chemoresistance. Moreover, an excessive periostin deposition exerts a pivotal role in remodeling various tumor microenvironments, such as cancer stem cell niche, perivascular niche, premetastatic niche, immunosuppressive microenvironment, bone marrow microenvironment and other tumor growth-supportive microenvironments. In this review, we provide an update understanding of the multifaceted functions and mechanisms of periostin in tumor development and progression.

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References

  1. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF (2004) Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 5:329–339

    CAS  PubMed  Google Scholar 

  2. Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR (2007) Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway. Oncogene 26:2082–2094

    CAS  PubMed  Google Scholar 

  3. Ben QW, Zhao Z, Ge SF, Zhou J, Yuan F, Yuan YZ (2009) Circulating levels of periostin may help identify patients with more aggressive colorectal cancer. Int J Oncol 34:821–828

    CAS  PubMed  Google Scholar 

  4. Ben QW, Jin XL, Liu J, Cai X, Yuan F, Yuan YZ (2011) Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer. Oncol Rep 25:709–716

    CAS  PubMed  Google Scholar 

  5. Bornstein P (1995) Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol 130:503–506

    Article  CAS  Google Scholar 

  6. Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR (2017) Transcriptional induction of periostin by a sulfatase 2-TGFβ1-SMAD signaling axis mediates tumor angiogenesis in hepatocellular carcinoma. Cancer Res 77:632–645

    Article  CAS  Google Scholar 

  7. Contié S, Voorzanger-Rousselot N, Litvin J, Clézardin P, Garnero P (2011) Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases. Int J Cancer 128:352–360

    Article  Google Scholar 

  8. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A (2014) The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 71:1279–1288

    Article  CAS  Google Scholar 

  9. Cui D, Huang Z, Liu Y, Ouyang G (2017) The multifaceted role of periostin in priming the tumor microenvironments for tumor progression. Cell Mol Life Sci 74:4287–4291

    Article  CAS  Google Scholar 

  10. Dong D, Zhang L, Jia L, Ji W, Wang Z, Ren L, Niu R, Zhou Y (2018) Identification of serum periostin as a potential diagnostic and prognostic marker for colorectal cancer. Clin Lab 64:973–981

    CAS  PubMed  Google Scholar 

  11. Duarte D, Hawkins ED, Lo Celso C (2018) The interplay of leukemia cells and the bone marrow microenvironment. Blood 131:1507–1511

    Article  CAS  Google Scholar 

  12. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Büchler MW, Giese NA, Friess H (2007) Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 132:1447–1464

    Article  CAS  Google Scholar 

  13. Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H (2015) Periostin is a key niche component for wound metastasis of melanoma. PLoS One 10:e0129704

    Article  Google Scholar 

  14. Fukushima N, Kikuchi Y, Nishiyama T, Kudo A, Fukayama M (2008) Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas. Mod Pathol 21:1044–1053

    Article  CAS  Google Scholar 

  15. Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ (2013) The perivascular niche regulates breast tumour dormancy. Nat Cell Biol 15:807–817

    Article  CAS  Google Scholar 

  16. Gineyts E, Bonnet N, Bertholon C, Millet M, Pagnon-Minot A, Borel O, Geraci S, Bonnelye E, Croset M, Suhail A, Truica C, Lamparella N, Leitzel K, Hartmann D, Chapurlat R, Lipton A, Garnero P, Ferrari S, Clézardin P, Rousseau JC (2018) The C-terminal intact forms of periostin (iPTN) are surrogate markers for osteolytic lesions in experimental breast cancer bone metastasis. Calcif Tissue Int. https://doi.org/10.1007/s00223-018-0444-y

    Article  CAS  Google Scholar 

  17. Hu W, Jin P, Liu W (2016) Periostin contributes to cisplatin resistance in human non-small cell lung cancer A549 cells via activation of Stat3 and Akt and upregulation of Survivin. Cell Physiol Biochem 38:1199–1208

    Article  CAS  Google Scholar 

  18. Hu WW, Chen PC, Chen JM, Wu YM, Liu PY, Lu CH, Lin YF, Tang CH, Chao CC (2017) Periostin promotes epithelial-mesenchymal transition via the MAPK/miR-381 axis in lung cancer. Oncotarget 8:62248–62260

    PubMed  PubMed Central  Google Scholar 

  19. Huang Y, Liu W, Xiao H, Maitikabili A, Lin Q, Wu T, Huang Z, Liu F, Luo Q, Ouyang G (2015) Matricellular protein periostin contributes to hepatic inflammation and fibrosis. Am J Pathol 185:786–797

    Article  CAS  Google Scholar 

  20. Jang SY, Park SY, Lee HW, Choi YK, Park KG, Yoon GS, Tak WY, Kweon YO, Hur K, Lee WK (2016) The combination of periostin overexpression and microvascular invasion is related to a poor prognosis for hepatocellular carcinoma. Gut Liver 10:948–954

    Article  CAS  Google Scholar 

  21. Kanno A, Satoh K, Masamune A, Hirota M, Kimura K, Umino J, Hamada S, Satoh A, Egawa S, Motoi F, Unno M, Shimosegawa T (2008) Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells. Int J Cancer 122:2707–2718

    Article  CAS  Google Scholar 

  22. Khurana S, Schouteden S, Manesia JK, Santamaria-Martínez A, Huelsken J, Lacy-Hulbert A, Verfaillie CM (2016) Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis. Nat Commun 7:13500

    Article  CAS  Google Scholar 

  23. Kii I, Ito H (2017) Periostin and its interacting proteins in the construction of extracellular architectures. Cell Mol Life Sci 74:4269–4277

    Article  CAS  Google Scholar 

  24. Kikuchi Y, Kunita A, Iwata C, Komura D, Nishiyama T, Shimazu K, Takeshita K, Shibahara J, Kii I, Morishita Y, Yashiro M, Hirakawa K, Miyazono K, Kudo A, Fukayama M, Kashima TG (2014) The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation. Am J Pathol 184:859–870

    Article  CAS  Google Scholar 

  25. Kudo A (2011) Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 68:3201–3207

    Article  CAS  Google Scholar 

  26. Kudo A (2017) Introductory review: periostin-gene and protein structure. Cell Mol Life Sci 74:4259–4268

    Article  CAS  Google Scholar 

  27. Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S (2016) Tumor cell-derived periostin regulates cytokines that maintain breast cancer stem cells. Mol Cancer Res 14:103–113

    Article  CAS  Google Scholar 

  28. Li JS, Sun GW, Wei XY, Tang WH (2007) Expression of periostin and its clinicopathological relevance in gastric cancer. World J Gastroenterol 13:5261–5266

    Article  CAS  Google Scholar 

  29. Li Y, Wu S, Xiong S, Ouyang G (2015) Deficiency of periostin protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis. J Hepatol 62:495–497

    Article  CAS  Google Scholar 

  30. Liu Y, Cao X (2016) Characteristics and significance of the pre-metastatic niche. Cancer Cell 30:668–681

    Article  CAS  Google Scholar 

  31. Liu AY, Zheng H, Ouyang G (2014) Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol 37:150–156

    Article  Google Scholar 

  32. Liu Y, Li F, Gao F, Xing L, Qin P, Liang X, Zhang J, Qiao X, Lin L, Zhao Q, Du L (2016) Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling. Oncotarget 7:40148–40159

    PubMed  PubMed Central  Google Scholar 

  33. Liu Y, Gao F, Song W (2017) Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia. Biomed Pharmacother 88:342–348

    Article  CAS  Google Scholar 

  34. Lv Y, Wang W, Jia WD, Sun QK, Li JS, Ma JL, Liu WB, Zhou HC, Ge YS, Yu JH, Xia HH, Xu GL (2013) High-level expression of periostin is closely related to metastatic potential and poor prognosis of hepatocellular carcinoma. Med Oncol 30:385

    Article  Google Scholar 

  35. Ma Z, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G, Ouyang G, Xiao C (2017) A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia 31:1835–1837

    Article  CAS  Google Scholar 

  36. Malanchi I, Santamaria-Martinez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J (2012) Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 481:85–89

    Article  CAS  Google Scholar 

  37. Marturano-Kruik A, Nava MM, Yeager K, Chramiec A, Hao L, Robinson S, Guo E, Raimondi MT, Vunjak-Novakovic G (2018) Human bone perivascular niche-on-a-chip for studying metastatic colonization. Proc Natl Acad Sci U S A 115:1256–1261

    Article  CAS  Google Scholar 

  38. Mikheev AM, Mikheeva SA, Trister AD, Tokita MJ, Emerson SN, Parada CA, Born DE, Carnemolla B, Frankel S, Kim DH, Oxford RG, Kosai Y, Tozer-Fink KR, Manning TC, Silber JR, Rostomily RC (2015) Periostin is a novel therapeutic target that predicts and regulates glioma malignancy. Neuro-Oncology 17:372–382

    Article  CAS  Google Scholar 

  39. Morra L, Rechsteiner M, Casagrande S, Duc Luu V, Santimaria R, Diener PA, Sulser T, Kristiansen G, Schraml P, Moch H, Soltermann A (2011) Relevance of periostin splice variants in renal cell carcinoma. Am J Pathol 179:1513–1521

    Article  CAS  Google Scholar 

  40. Morra L, Rechsteiner M, Casagrande S, Von Teichman A, Schraml P, Moch H, Soltermann A (2012) Characterization of periostin isoform pattern in non-small cell lung cancer. Lung Cancer 76:183–190

    Article  Google Scholar 

  41. Müller-Greven G, Carlin CR, Burgett ME, Ahluwalia MS, Lauko A, Nowacki AS, Herting CJ, Qadan MA, Bredel M, Toms SA, Lathia JD, Hambardzumyan D, Sarkaria JN, Hamerlik P, Gladson CL (2017) Macropinocytosis of bevacizumab by glioblastoma cells in the perivascular niche affects their survival. Clin Cancer Res 23:7059–7071

    Article  Google Scholar 

  42. Murphy-Ullrich JE, Sage EH (2014) Revisiting the matricellular concept. Matrix Biol 37:1–14

    Article  CAS  Google Scholar 

  43. Nakama T, Yoshida S, Ishikawa K, Kobayashi Y, Abe T, Kiyonari H, Shioi G, Katsuragi N, Ishibashi T, Morishita R, Taniyama Y (2016) Different roles played by periostin splice variants in retinal neovascularization. Exp Eye Res 153:133–140

    Article  CAS  Google Scholar 

  44. Nakazawa Y, Taniyama Y, Sanada F, Morishita R, Nakamori S, Morimoto K, Yeung KT, Yang J (2018) Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer. Sci Rep 8:4013

    Article  Google Scholar 

  45. Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, Engle D, Campbell F, Palmer D, Ko JH, Tuveson DA, Hirsch E, Mielgo A, Schmid MC (2016) Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol 18:549–560

    Article  CAS  Google Scholar 

  46. Nuzzo PV, Rubagotti A, Zinoli L, Ricci F, Salvi S, Boccardo S, Boccardo F (2012) Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death. BMC Cancer 12:625

    Article  Google Scholar 

  47. Nuzzo PV, Rubagotti A, Argellati F, Di Meglio A, Zanardi E, Zinoli L, Comite P, Mussap M, Boccardo F (2015) Prognostic value of preoperative serum levels of periostin (PN) in early breast cancer (BCa). Int J Mol Sci 16:17181–17192

    Article  CAS  Google Scholar 

  48. Omary MB, Lugea A, Lowe AW, Pandol SJ (2007) The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest 117:50–59

    Article  CAS  Google Scholar 

  49. Ouanouki A, Lamy S, Annabi B (2018) Periostin, a signal transduction intermediate in TGF-beta-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins. Oncotarget 9:22023–22037

    Article  Google Scholar 

  50. Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S (2009) Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett 281:213–219

    Article  CAS  Google Scholar 

  51. Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D (2017) Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17:302–317

    Article  CAS  Google Scholar 

  52. Pothula SP, Xu Z, Goldstein D, Pirola RC, Wilson JS, Apte MV (2016) Key role of pancreatic stellate cells in pancreatic cancer. Cancer Lett 381:194–200

    Article  CAS  Google Scholar 

  53. Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nat Med 19:1423–1437

    Article  CAS  Google Scholar 

  54. Ratajczak-Wielgomas K, Grzegrzolka J, Piotrowska A, Gomulkiewicz A, Witkiewicz W, Dziegiel P (2016) Periostin expression in cancer-associated fibroblasts of invasive ductal breast carcinoma. Oncol Rep 36:2745–2754

    Article  CAS  Google Scholar 

  55. Ruan K, Bao S, Ouyang G (2009) The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 66:2219–2230

    Article  CAS  Google Scholar 

  56. Ryner L, Guan Y, Firestein R, Xiao Y, Choi Y, Rabe C, Lu S, Fuentes E, Huw LY, Lackner MR, Fu L, Amler LC, Bais C, Wang Y (2015) Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer. Clin Cancer Res 21:2941–2951

    Article  CAS  Google Scholar 

  57. Sasaki H, Yu CY, Dai M, Tam C, Loda M, Auclair D, Chen LB, Elias A (2003) Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer. Breast Cancer Res Treat 77:245–252

    Article  CAS  Google Scholar 

  58. Schneider G, Schmidt-Supprian M, Rad R, Saur D (2017) Tissue-specific tumorigenesis: context matters. Nat Rev Cancer 17:239–253

    Article  CAS  Google Scholar 

  59. Semba T, Sugihara E, Kamoshita N, Ueno S, Fukuda K, Yoshino M, Takao K, Yoshikawa K, Izuhara K, Arima Y, Suzuki M, Saya H (2018) Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma. Cancer Sci 109:1447–1454

    Article  CAS  Google Scholar 

  60. Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang XF (2004) Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol 24:3992–4003

    Article  CAS  Google Scholar 

  61. Siriwardena BS, Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Hatano H, Tilakaratne WM, Miyauchi M, Takata T (2006) Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer 95:1396–1403

    Article  CAS  Google Scholar 

  62. Tai IT, Dai M, Chen LB (2005) Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis 26:908–915

    Article  CAS  Google Scholar 

  63. Tilman G, Mattiussi M, Brasseur F, Van Baren N, Decottignies A (2007) Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells. Mol Cancer 6:80

    Article  Google Scholar 

  64. Vardaki I, Ceder S, Rutishauser D, Baltatzis G, Foukakis T, Panaretakis T (2016) Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes. Oncotarget 7:74966–74978

    Article  Google Scholar 

  65. Wang Z, Ouyang G (2012) Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell 10:111–112

    Article  CAS  Google Scholar 

  66. Wang H, Wang Y, Jiang C (2013a) Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. Int J Oncol 42:1716–1724

    Article  Google Scholar 

  67. Wang X, Liu J, Wang Z, Huang Y, Liu W, Zhu X, Cai Y, Fang X, Lin S, Yuan L, Ouyang G (2013b) Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS One 8:e72962

    Article  CAS  Google Scholar 

  68. Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G (2016) Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol 239:484–495

    Article  CAS  Google Scholar 

  69. Wculek SK, Malanchi I (2015) Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature 528:413–417

    Article  CAS  Google Scholar 

  70. Wu T, Wu S, Ouyang G (2014) Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metab 20:562–564

    Article  CAS  Google Scholar 

  71. Wu T, Huang J, Wu S, Huang Z, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F, Ouyang G (2018) Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biol 66:81–92

    Article  CAS  Google Scholar 

  72. Xu D, Xu H, Ren Y, Liu C, Wang X, Zhang H, Lu P (2012) Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer. PLoS One 7:e46670

    Article  CAS  Google Scholar 

  73. Xu X, Chang W, Yuan J, Han X, Tan X, Ding Y, Luo Y, Cai H, Liu Y, Gao X, Liu Q, Yu Y, Du Y, Wang H, Ma L, Wang J, Chen K, Ding Y, Fu C, Cao G (2016) Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche. Oncotarget 7:798–813

    PubMed  Google Scholar 

  74. Xu CH, Wang W, Lin Y, Qian LH, Zhang XW, Wang QB, Yu LK (2017) Diagnostic and prognostic value of serum periostin in patients with non-small cell lung cancer. Oncotarget 8:18746–18753

    PubMed  Google Scholar 

  75. Yamada S, Tauchi T, Awata T, Maeda K, Kajikawa T, Yanagita M, Murakami S (2014) Characterization of a novel periodontal ligament-specific periostin isoform. J Dent Res 93:891–897

    Article  CAS  Google Scholar 

  76. Zhang R, Yao RR, Li JH, Dong G, Ma M, Zheng QD, Gao DM, Cui JF, Ren ZG, Chen RX (2017) Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment. Sci Rep 7:2164

    Article  Google Scholar 

  77. Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, Wu L, Sloan AE, McLendon RE, Li X, Rich JN, Bao S (2015) Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 17:170–182

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81572598, 81772616, 31800970) and the Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University (SKLCSB2017KF007, SKLCSB2016KF004).

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  1. Authors Yingfu Liu, Zhengjie Huang and Dan Cui have been equally contributed to this chapter.

Authors and Affiliations

  1. Department of Basic Medical Sciences, Cancer Research Center, School of Medicine, Xiamen University, Xiamen, China

    Yingfu Liu

  2. State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China

    Yingfu Liu, Dan Cui & Gaoliang Ouyang

  3. First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China

    Zhengjie Huang

  4. Engineering Research Center of Molecular Diagnostics, Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China

    Gaoliang Ouyang

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  1. Yingfu Liu
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  1. International Frontier, Tokyo Institute of Technology, Tokyo, Japan

    Akira Kudo

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Liu, Y., Huang, Z., Cui, D., Ouyang, G. (2019). The Multiaspect Functions of Periostin in Tumor Progression. In: Kudo, A. (eds) Periostin. Advances in Experimental Medicine and Biology, vol 1132. Springer, Singapore. https://doi.org/10.1007/978-981-13-6657-4_13

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