Abstract
AGC kinases are important regulators of cell growth, metabolism, division, and survival in mammalian systems. Mutation or deregulation of members of this family of protein kinases contribute to the pathogenesis of many human diseases, including cancer and diabetes. Although AGC kinases are conserved in the plant kingdom, little is known about their molecular functions and targets. Some of the best-studied plant AGC kinases mediate auxin signaling and are thereby involved in the regulation of growth and morphogenesis. Furthermore, certain members are regulated by lipid-derived signals via the 3-phosphoinositide-dependent kinase 1 (PDK1) and the kinase target of rapamycin (TOR), similar to its animal counterparts. In this review, we discuss recent findings on plant AGC kinases that unravel important roles in the regulation of plant growth, immunity and cell death, and connections to stress-induced mitogen-activated protein kinase signaling cascades.
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The project is supported by funding from the following projects: ANR MAPK, EU ADYSARC, and Systems Biology SHIPREC. Due to space limitations, we apologize to all colleagues whose work has not been included in the review.
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Garcia, A.V., Al-Yousif, M. & Hirt, H. Role of AGC kinases in plant growth and stress responses. Cell. Mol. Life Sci. 69, 3259–3267 (2012). https://doi.org/10.1007/s00018-012-1093-3
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DOI: https://doi.org/10.1007/s00018-012-1093-3