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Effects of tranylcypromine on the concentrations of some trace amines in the diencephalon and hippocampus of the rat

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Summary

Concentrations of 4 trace amines in diencephalon and hippocampus of the rat were measured by integrated-ioncurrent mass spectrometry after administration of the antidepressant drug, tranylcypromine. Much larger increases were observed for 2-phenylethylamine and tryptamine than for m- and p-tyramine.

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Author notes

  1. G. B. Baker & H. R. McKim

    Present address: Department of Psychiatry, University of Alberta, Clinical Sciences Building, T6H 2G3, Edmonton, Alberta, Canada

Authors and Affiliations

  1. Psychiatric Research Division, University Hospital, S7N OXO, Saskatoon, Saskatchewan

    S. R. Philips, G. B. Baker & H. R. McKim

  2. Department of Psychiatry, University of Alberta, Clinical Sciences Building, T6H 2G3, Edmonton, Alberta, Canada

    S. R. Philips

Authors
  1. S. R. Philips
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  2. G. B. Baker
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  3. H. R. McKim
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Additional information

Financial support has been provided by the Medical Research Council of Canada, the Psychiatric Services Branch, Province of Saskatchewan, the Alberta Mental health Research Fund, and the Special Services and Research Committee, University of Alberta Hospital.

Acknowledgments. The authors wish to thank Dr B.A. Davis for synthesizing the deuterated internal standards and Dr D.A. Durden for supervising the mass spectral analyses. Expert technical assistance was provided by Mr R.C. Mag-Atas and Ms D.G. Calverley. The advice and encouragement of Professors W. G. Dewhurst and A. A. Boulton are gratefully acknowledged.

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Philips, S.R., Baker, G.B. & McKim, H.R. Effects of tranylcypromine on the concentrations of some trace amines in the diencephalon and hippocampus of the rat. Experientia 36, 241–242 (1980). https://doi.org/10.1007/BF01953756

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