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Effects of tranylcypromine and pargyline on brain tryptamine

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Summary

Tranylcypromine produces behavioral excitation while pargyline produces depression. Tranylcypromine increased brain tryptophan which led to an accumulation of tryptamine. The levels of tryptamine after tranylcypromine were found to be 3 times those found after pargyline.

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Literatur

  1. J. A. Saavaedra and J. Axelrod, J. Pharmac. exp. Ther.185, 523 (1973).

    Google Scholar 

  2. S. R. Philips, D. A. Durden and A. A. Boulton, Can. J. Biochem.52, 447 (1974).

    Article  CAS  PubMed  Google Scholar 

  3. A. A. Boulton, Adv. Biochem. Psychopharmac.15, 57 (1976).

    CAS  Google Scholar 

  4. S. R. Snodgrass and A. S. Horn, J. Neurochem.2, 687 (1973).

    Article  Google Scholar 

  5. A. Coppen, J. Psychiat. Res.9, 163 (1972).

    Article  CAS  PubMed  Google Scholar 

  6. A. Foldes and E. Costa, Biochem. Pharmac.24, 1617 (1975).

    Article  CAS  Google Scholar 

  7. B. Tabakoff and F. Moses, Biochem. Pharmac.25, 2555 (1976).

    Article  CAS  Google Scholar 

  8. D. G. Grahame-Smith, J. Neurochem.18, 1053 (1971).

    Article  CAS  PubMed  Google Scholar 

  9. S. R. Philips, D. A. Durden and A. A. Boulton, Can. J. Biochem.52, 447 (1974).

    Article  CAS  PubMed  Google Scholar 

  10. E. Marley and G. Nistico, Br. J. Pharmac.53, 193 (1975).

    Article  CAS  Google Scholar 

  11. W. G. Dewhurst and E. Marley, Br. J. Pharmac. Chemother.25, 705 (1965).

    Article  CAS  Google Scholar 

  12. W. G. Dewhurst, Nature218, 1130 (1968).

    Article  CAS  PubMed  Google Scholar 

  13. J. A. Bell and W. R. Martin, J. Pharmac. exp. Ther.196, 373 (1976).

    CAS  Google Scholar 

  14. R. J. Ziance, Fed. Proc.35 (3), 266 (1976).

    Google Scholar 

  15. E. D. Hendley and S. H. Snyder, Nature220, 1330 (1968).

    Article  CAS  PubMed  Google Scholar 

  16. A. A. Boulton and L. E. Dyck, Life Sci.14, 2497 (1974).

    Article  CAS  PubMed  Google Scholar 

  17. A. A. Boulton, L. E. Dyck and D. A. Durden, Life Sci.15, 1673 (1974).

    Article  CAS  PubMed  Google Scholar 

  18. L. E. Dyck and A. A. Boulton, Res. Com. Chem. Path. Pharmac.11, 73 (1975).

    CAS  Google Scholar 

  19. J. I. Escobar, B. C. Schiele and R. Zimmermann, Am. J. Psychiat.131, 1025 (1974).

    Article  CAS  PubMed  Google Scholar 

  20. A. H. Glassman and S. R. Platman, J. Psychiat. Res.7, 63 (1970).

    Google Scholar 

  21. C. M. B. Pare, Lancet,2, 527 (1963).

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. S. R. Philips & A. A. Boulton

    Present address: Psychiatric Research Unit, University Hospital, Saskatoon, Saskatchewan, Canada

Authors and Affiliations

  1. Department of Physiology, University of Illinois Medical Center, 901 South Wolcott Street, 60612, Chicago, Illinois, USA

    B. Tabakoff (Schweppe Foundation Fellow), Frances Moses, S. R. Philips & A. A. Boulton

  2. Psychiatric Research Unit, University Hospital, Saskatoon, Saskatchewan, Canada

    B. Tabakoff (Schweppe Foundation Fellow) & Frances Moses

Authors
  1. B. Tabakoff
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  2. Frances Moses
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  3. S. R. Philips
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  4. A. A. Boulton
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Additional information

This work was supported in part by U. S. Public Health Service Grants NS-12759 and AA-2696, State of Illinois Department of Mental Health, the Psychiatric Services Branch, Province of Saskatchewan, and the Medical Research Council of Canada, who have provided continuing financial support.

Acknowledgments. We thank Dr B. A. Davis for synthesizing the deuterated internal standards, Dr D. A. Durden for supervising the mass spectrometric analyses, and Mr H. Miyashita, Mr N. F. Binder and Miss E. E. Johnson for skilled technical assistance.

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Tabakoff, B., Moses, F., Philips, S.R. et al. Effects of tranylcypromine and pargyline on brain tryptamine. Experientia 33, 380–381 (1977). https://doi.org/10.1007/BF02002839

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  • DOI: https://doi.org/10.1007/BF02002839

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