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Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity

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Abstract

To investigate the relation between secondary hyperparathyroidism (SHPT) and insulin sensitivity, 15 subjects with SHPT (serum PTH >6.4 pmol/l, serum calcium <2.40 mmol/l, and normal serum creatinine) and 15 control subjects were investigated with an oral glucose tolerance test (OGTT) and a 3-h hyperglycemic clamp. Body composition was measured with dual-energy X-ray absorptiometry. No differences were found between the SHPT and control groups on any indices of glucose or insulin metabolism. However, when dividing the 30 subjects in the upper and lower halves according to serum 25-hydroxyvitamin D levels (<59 and >58 nmol/l), those in the lower half had significantly higher 2-h serum insulin value at the OGTT, significantly higher insulin secretion during the last hour of the clamp, andsignificantly lower insulin sensitivity index (ISI; glucose infusion rate/insulin secretion during the last hour of the clamp). In a multiple linear regression analysis correcting for age, gender, and body mass index (BMI), the serum 25-hydroxyvitamin D level was significantly and positively associated with the ISI. The amounts of total body and truncal fat were negatively and significantly associated with the ISI, whereas no association between measures of lean body mass were associated with insulin secretion or sensitivity.

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Authors and Affiliations

  1. Department of Medicine, University Hospital of North Norway, Tromsø, Norway

    E. Kamycheva & R. Jorde

  2. Institute of Clinical Medicine, University Hospital of North Norway, Tromsø, Norway

    R. Jorde

  3. Department of Clinical Chemistry, University Hospital of North Norway, Tromsø

    Y. Figenschau

  4. Hormone Laboratory, Aker University Hospital, Oslo, Norway

    E. Haug

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  1. E. Kamycheva
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  2. R. Jorde
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  3. Y. Figenschau
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  4. E. Haug
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Correspondence to E. Kamycheva.

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Kamycheva, E., Jorde, R., Figenschau, Y. et al. Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity. J Endocrinol Invest 30, 126–132 (2007). https://doi.org/10.1007/BF03347410

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  • DOI: https://doi.org/10.1007/BF03347410

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