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Promotion of cellular NAD+ anabolism: Therapeutic potential for oxidative stress in ageing and alzheimer’s disease

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Abstract

Oxidative imbalance is a prominent feature in Alzheimer’s disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer’s disease, in particular.

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  1. Faculty of Medicine, University of New South Wales, Sydney, Australia

    Nady Braidy, Gilles Guillemin & Ross Grant

  2. Centre for Immunology, St Vincent’s Hospital, Sydney, Australia

    Gilles Guillemin

  3. Australasian Research Institute, Sydney Adventist Hospital, Sydney, Australia

    Ross Grant

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  1. Nady Braidy
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  2. Gilles Guillemin
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Correspondence to Ross Grant.

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Braidy, N., Guillemin, G. & Grant, R. Promotion of cellular NAD+ anabolism: Therapeutic potential for oxidative stress in ageing and alzheimer’s disease. neurotox res 13, 173–184 (2008). https://doi.org/10.1007/BF03033501

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