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Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease

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Abstract

Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.

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Authors and Affiliations

  1. Department of Anatomy, St. George's Hospital Medical School, Cranmer Terrace, Tooting, SW17 0RE, London, UK

    N. Horwood & D. C. Davies

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  1. N. Horwood
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  2. D. C. Davies
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Horwood, N., Davies, D.C. Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease. Vichows Archiv A Pathol Anat 425, 69–72 (1994). https://doi.org/10.1007/BF00193951

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  • DOI: https://doi.org/10.1007/BF00193951

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