Summary
Two lines of mice have been established in which off-white regions occur scattered all over the coat. These lines are called Mottled and Brindled respectively. This character is dominant to the normal coat, and correlated with a marked degree of inviability which is sex-modified. In the Mottled line, no mottled males have been classified and differences of the sex-ratio and litter size show this deficiency to be probably due to a pre-natal lethality of the Mottled factor in all males. In the Brindled line all brindled males survive to classification, but none survives past 3 weeks from birth. It is suggested that the similarities, both of phenotype and of inheritance, between Mottled and Brindled argue a similar genetic determination.
The analysis of Mottled was made whilst A.S.F. held a maintenance grant from the Agricultural Eesearch Council.
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References
Falconer, D. S. (1949). The estimation of mutation rates from incompletely tested gametes. J.Genet. 49, 226–34.
Grüneberg, H. (1943).The Genetics of the Mouse. London.
Wriget, M. E. (1947). Two sex-linkages in the house mouse with unusual recombination values.Heredity, 1, 349.
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Frasee, A.S., Sobey, S. & Spicer, C.C. Mottled, a sex-modified lethal in the house mouse. Journ. of Genetics 51, 217–221 (1953). https://doi.org/10.1007/BF03023293
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DOI: https://doi.org/10.1007/BF03023293