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Mouse Genetics and Breeding

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Essentials of Laboratory Animal Science: Principles and Practices

Abstract

The laboratory mouse (Mus musculus) has been employed in biomedical research for its amenability to genetic modification. The genetic modifications have enabled the development of new mouse strains for studying diverse diseases. This chapter will provide information on mouse genetics, their nomenclature, and different strategies of breeding. This chapter will also describe the genetic monitoring program and quality control program associated with it. For ease of learning, we have classified the chapter into four broad categories—selection aids, selection methods, mating aids, and mating methods to facilitate a deeper understanding of mouse genetics and breeding.

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Abbreviations

GEM:

Genetically engineered mice

MGI:

Mouse genome informatics

MPD:

Mouse phenome database

NCBI:

National center for biotechnology information

PCR:

Polymerase chain reaction

SNP:

Single-nucleotide polymorphism

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Author information

Authors and Affiliations

  1. Tamil Nadu Veterinary and Animal Science University, Chennai, Tamil Nadu, India

    Satheesh Kumar Panneer

  2. Experimental Animal Facility, National Institute of Immunology, New Delhi, India

    Shailendra Kumar Arindkar

  3. National Institute of Immunology, New Delhi, India

    Perumal Nagarajan

Authors
  1. Satheesh Kumar Panneer
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  2. Shailendra Kumar Arindkar
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  3. Perumal Nagarajan
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Corresponding author

Correspondence to Perumal Nagarajan .

Editor information

Editors and Affiliations

  1. Experimental Animal Facility, National Institute of Immunology, New Delhi, Delhi, India

    P. Nagarajan

  2. Central Animal Facility, Indian Institute of Science, Bangalore, Karnataka, India

    Ramachandra Gudde

  3. Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India

    Ramesh Srinivasan

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Panneer, S.K., Arindkar, S.K., Nagarajan, P. (2021). Mouse Genetics and Breeding. In: Nagarajan, P., Gudde, R., Srinivasan, R. (eds) Essentials of Laboratory Animal Science: Principles and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-16-0987-9_15

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