Summary
It has been shown that a continuous infusion of ketamine during one-lung anaesthesia combined with a 50 per cent oxygen-curare anaesthetic technique will provide consistently lower shunt fraction and higher\(Pa_{o_2 } \) compared with halo-thane under the same experimental conditions.
Because no additional factor was observed which could account for these changes and because the responses of the animals to the two anaesthetic agents were similar — the only difference being a different initial set point — the experimental model may be considered adequate. In the authors’ view the difference in shunt fractions may be attributed to a more stable hypoxic reflex during ketamine anaesthesia.
Further experimentation will be necessary to fully exclude the possibility of sequence-related changes affecting some of these results and to determine whether or not certain groups of dogs respond in a qualitatively different fashion.
Résumé
Ce travail a démontré qu’une infusion continue de kétamine associée à une anesthésie par inhalation au moyen de protoxyde ďazote à 50 pour cent chez des chiens curarisés assurait de façon constante une\(Pa_{o_2 } \) supérieure et un shunt moindre par comparaison aux résultats observés lorsque ľanesthésie était effectuée avec un mélange de protoxyde ďazote à 50 pour cent ďhalothane et oxygène, ceci en situations de poumon exclu (tube endotrachéal poussé dans une bronche et ballonnet gonflé). Ces résultats semblent dus à un réflexe de vasoconstriction à ľhypoxie mieux conservé sous anesthésie à la kétamine. Les auteurs estiment cependant nécessaire de poursuivre leur étude afin de confirmer leur conclusion.
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Lumb, P.D., Silvay, G., Weinreich, A.I. et al. A comparison of the effects of continuous ketamine infusion and halothane on oxygenation during one-lung anaesthesia in dogs. Canad.Anaes.Soc.J. 26, 394–401 (1979). https://doi.org/10.1007/BF03006454
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DOI: https://doi.org/10.1007/BF03006454