Summary
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1.
The importance of mapping the chromosomes of the mouse is stressed, and the need for specially designed stocks for routine linkage testing is pointed out.
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2.
The theory of planning linkage tests is outlined, and the new concept of ‘swept radius’ is introduced. This makes it possible (a) to decide, on the basis of efficiency, between a number of alternative procedures that present themselves in the planning of linkage tests; and (b) to design special linkage testing stocks.
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3.
The composition of five specially designed linkage testing stocks is described. By the use of these stocks a gene can be tested against a little over half of the total genetic map, at the cost of raising about 500 test progeny, which is a considerable improvement over what is at present possible.
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4.
An outline is given in Appendix I of the procedure to be adopted for the use of the stocks.
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Carter, T.C., Falconer, D.S. Stocks for detecting linkage in the mouse, and the theory of their design. Journ. of Genetics 50, 307–323 (1951). https://doi.org/10.1007/BF02996226
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DOI: https://doi.org/10.1007/BF02996226