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The detection of autosomal lethals in mice induced by mutagenic agents

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Summary

A method is proposed for searching for recessive lethals in mice. A multiple recessive stock is irradiated, and members of it are crossed to a multiple dominant stock. Lethal genes are detected by deficiencies of recessives inF 2. The length of chromosome searched is evaluated. It should be possible to search about 6 % of the genetical map in eachF 2.

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Authors and Affiliations

  1. Department of Biometry, University College London, London

    J. B. S. Haldane

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  1. J. B. S. Haldane
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Haldane, J.B.S. The detection of autosomal lethals in mice induced by mutagenic agents. J Genet 54, 327–342 (1956). https://doi.org/10.1007/BF02982787

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  • DOI: https://doi.org/10.1007/BF02982787

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