Summary
The regeneration of nevus cells after shave biopsy was investigated by means of fluorescence-histochemical and electron microscopic methods. A prerequisite for the regeneration of pigmented nevi seems to be the retention of their deepest part. It appears that the remaining nevus cells primarily induce proliferation of pigment-producing dendritic cells in the epidermis. These dendritic cells form nest-like conglomerations at the dermal-epidermal junction, which eventually separate from the epidermis during a process called “dropping off”. The fluorescencehistochemical and electron-microscopic results lead to the conclusion that under these circumstances melanocytes are transformed into nevus cells.
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The electron-microscopical findings will be presented in detail by H. Gerhard as Inaugural-Dissertation to the Fachbereich Medizin, Justus-Liebig-Universität Giessen
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Paul, E., Gerhard, H. Morphologic investigations on the dynamics of nevus development. Virchows Archiv B Cell Pathol 43, 337–348 (1983). https://doi.org/10.1007/BF02932966
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DOI: https://doi.org/10.1007/BF02932966