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Nevi (Benign Melanocytic)

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European Handbook of Dermatological Treatments

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Abstract

Melanocytic nevi are benign hamartomas of the skin composed of nevus cells. They are almost always present in fair-skinned individuals and can arise in any anatomic site. When present at birth or during the first 2 years of life, they are categorized as congenital nevi. Melanocytic nevi that show up later in life are described as acquired nevi. The latter are further classified into common acquired nevus, dysplastic (atypical) nevus, blue nevus, Spitz nevus, and halo nevus. Their association with melanoma seems to depend on the total number and the specific types of melanocytic nevi. Regarding their benign nature, usually they do not require any therapeutic intervention. However nevi at special anatomic sites, atypical nevi, or nevi with an intriguing clinical-dermoscopic presentation should be followed up with dermoscopy in a more regular basis.

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Further Reading

  • Ackerman AB, Milde P. Naming acquired melanocytic nevi. Common and dysplastic, normal and atypical, or Unna, Miescher, Spitz, and Clark? Am J Dermatopathol. 1992;14:447–53.

    Article  CAS  Google Scholar 

  • Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: where are we now? Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol. 2012;67:495.e1–17.

    Article  Google Scholar 

  • Barnhill RL, Barnhill MA, Berwick M, Mihm Jr MC. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum Pathol. 1991;22:52–8.

    Article  CAS  Google Scholar 

  • Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol. 1999;30:513–20.

    Article  CAS  Google Scholar 

  • Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons. J Am Acad Dermatol. 2005;52:793–7.

    Article  Google Scholar 

  • Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol. 2003;139:1620–4.

    Article  Google Scholar 

  • Casso EM, Grin-Jorgensen CM, Grant-Kels JM. Spitz nevi. J Am Acad Dermatol. 1992;27:901–13.

    Article  CAS  Google Scholar 

  • Celebi JT, Ward KM, Wanner M, Polsky D, Kopf AW. Evaluation of germline CDKN2A, ARF, CDK4, PTEN, and BRAF alterations in atypical mole syndrome. Clin Exp Dermatol. 2005;30:68–70.

    Article  CAS  Google Scholar 

  • Clarke LE. Dysplastic nevi. Clin Lab Med. 2011;31:255–65.

    Article  Google Scholar 

  • De Snoo FA, Kroon MW, Bergman W, ter Huurne JE, Houwing-Duistermaat JJ, van Mourik L, et al. From sporadic atypical nevi to familial melanoma: risk analysis for melanoma in sporadic atypical nevus patients. J Am Acad Dermatol. 2007;56:748–52.

    Article  Google Scholar 

  • DeDavid M, Orlow SJ, Provost N, et al. A study of large congenital melanocytic nevi and associated malignant melanomas: review of cases in the New York University Registry and the world literature. J Am Acad Dermatol. 1997;36:409–16.

    Article  CAS  Google Scholar 

  • Ferrara G, Argenziano G, Soyer HP, et al. The spectrum of Spitz nevi: a clinicopathologic study of 83 cases. Arch Dermatol. 2005;141:1381–7.

    Article  Google Scholar 

  • Gallagher RP, McLean DI. The epidemiology of acquired melanocytic nevi. A brief review. Dermatol Clin. 1995;13:595–603.

    Article  CAS  Google Scholar 

  • Gelbard SN, Tripp JM, Marghoob AA, et al. Management of Spitz nevi: a survey of dermatologists in the United States. J Am Acad Dermatol. 2002;47:224–30.

    Article  Google Scholar 

  • Geller AC, Swetter SM, Brooks K, Demierre MF, Yaroch AL. Screening, early detection, and trends for melanoma: current status (2000–2006) and future directions. J Am Acad Dermatol. 2007;57:555–72.

    Article  Google Scholar 

  • Haenssle HA, Korpas B, Hansen-Hagge C, Buhl T, Kaune KM, Johnsen S, Rosenberger A, Schön MP, Emmert S. Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Arch Dermatol. 2010;146(3):257–64.

    Article  Google Scholar 

  • Harrison SL, MacLennan R, Buettner PG. Sun exposure and the incidence of melanocytic nevi in young Australian children. Cancer Epidemiol Biomarkers Prev. 2008;17:2318–24.

    Article  CAS  Google Scholar 

  • Ibrahimi OA, Alikhan A, Eisen DB. Congenital melanocytic nevi: where are we now? Part II. Treatment options and approach to treatment. J Am Acad Dermatol. 2012;67:515.e1–13.

    Article  Google Scholar 

  • Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol. 2006;155:1–8.

    Article  CAS  Google Scholar 

  • Lambert WC, Brodkin RH. Nodal and subcutaneous cellular blue nevi. A pseudometastasizing pseudomelanoma. Arch Dermatol. 1984;120:367–70.

    Article  CAS  Google Scholar 

  • Lovett A, Maari C, Decarie JC, et al. Large congenital melanocytic nevi and neurocutaneous melanocytosis: one pediatric center’s experience. J Am Acad Dermatol. 2009;61:766–74.

    Article  Google Scholar 

  • Marghoob AA, Schoenbach SP, Kopf AW, et al. Large congenital melanocytic nevi and the risk for the development of malignant melanoma. A prospective study. Arch Dermatol. 1996;132(2):170–5.

    Article  CAS  Google Scholar 

  • Marinkovic M, Janjic Z, Nikolic J. Dysplastic nevus–a risk factor of developing skin melanoma clinical and epidemiological study with retrospective review of literature. Med Pregl. 2011;64:315–8.

    Article  Google Scholar 

  • Menzies SW, Stevenson ML, Altamura D, Byth K. Variables predicting change in benign melanocytic nevi undergoing short-term dermoscopic imaging. Arch Dermatol. 2011;147(6):655–9.

    Article  Google Scholar 

  • Monteagudo B, Labandeira J, Acevedo A, et al. Prevalence and clinical features of congenital melanocytic nevi in 1,000 Spanish newborns. Actas Dermosifiliogr. 2011;102:114–20.

    Article  CAS  Google Scholar 

  • Murali R, McCarthy SW, Scolyer RA. Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfalls. Adv Anat Pathol. 2009;16:365–82.

    Article  Google Scholar 

  • Rodriguez HA, Ackerman LV. Cellular blue nevus. Clinicopathologic study of forty-five cases. Cancer. 1968;21:393–405.

    Article  CAS  Google Scholar 

  • Sepehr A, Chao E, Trefrey B, et al. Long-term outcome of Spitz-type melanocytic tumors. Arch Dermatol. 2011;147:1173–9.

    Article  Google Scholar 

  • Van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol. 2011;164:743–9.

    Article  Google Scholar 

  • Zaal LH, Mooi WJ, Klip H, van der Horst CM. Risk of malignant transformation of congenital melanocytic nevi: a retrospective nationwide study from The Netherlands. Plast Reconstr Surg. 2005;116:1902–9.

    Article  CAS  Google Scholar 

  • Zalaudek I, Schmid K, Marghoob AA, et al. Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. Arch Dermatol. 2011;147(6):663–70.

    Article  Google Scholar 

  • Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997;37:620–4.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, “Attikon” University Hospital, Athens, Greece

    Alexander C. Katoulis & Dimitrios Sgouros

  2. Professor Emeritus of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, Athens, Greece

    Nikolaos G. Stavrianeas

Authors
  1. Alexander C. Katoulis
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  2. Dimitrios Sgouros
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  3. Nikolaos G. Stavrianeas
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Correspondence to Alexander C. Katoulis .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Andreas Syggros Hospital University of Athens, Athens, Greece

    Andreas D. Katsambas  & Clio Dessinioti  & 

  2. University of Rome “G. Marconi”, Rome, Italy

    Torello M. Lotti

  3. Centro Studi per la Ricerca Multidisciplinare Rigenerativa (CSRMR), Rome, Italy

    Torello M. Lotti

  4. Unit of Dermatology, University of Pisa, Pisa, Italy

    Angelo Massimiliano D’Erme

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Katoulis, A.C., Sgouros, D., Stavrianeas, N.G. (2015). Nevi (Benign Melanocytic). In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_65

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  • DOI: https://doi.org/10.1007/978-3-662-45139-7_65

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45138-0

  • Online ISBN: 978-3-662-45139-7

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