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The Dual Pathway of Nevogenesis

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Nevogenesis

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Abstract

The evolution of melanocytic nevi is a complex, multifactorial process involving both constitutional and environmental factors. While histopathology remains the gold standard for diagnosis of melanocytic lesions, it is a mere cross-sectional view of nevus evolution at one point in time. Dermoscopy and more recently, reflectance confocal microscopy (RCM) are in vivo diagnostic techniques for the assessment of morphologic features of nevi; the fact that most dermoscopic features are well correlated with histopathologic criteria makes these methods valuable for observing gross tissue changes of nevi over time without need to biopsy (Table 4.1). Thus, dermoscopy and RCM have enriched profoundly our knowledge about the morphological variability of nevi and offered new insights into their evolution.

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Author information

Authors and Affiliations

  1. Dermatology and Skin Cancer Unit, Medical University of Graz, Auenbruggerplatz 8, Graz, 8036, Italy

    Iris Zalaudek M.D.

  2. Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Viale Risorgimento 80, Reggio Emilia, 42100, Italy

    Iris Zalaudek M.D., Giuseppe Argenziano M.D. & Caterina Longo M.D.

  3. Memorial Sloan-Kettering Skin Cancer Center, Hauppauge, New York, USA

    Ashfaq A. Marghoob M.D.

  4. Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 East 53rd St., 10022, New York, NY, USA

    Alon Scope M.D.

  5. Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel

    Alon Scope M.D.

  6. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Alon Scope M.D.

  7. Pathology Unit, Arcispedale Santa Maria Nuova, Viale Risorgimento 80, Reggio Emilia, 42100, Italy

    Simonetta Piana M.D.

  8. Department of Oncologic Dermatology, San Gallicano Dermatological Institute, Via Elio Chianesi, 53 00144, Rome, Italy

    Caterina Carticalà M.D.

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  1. Iris Zalaudek M.D.
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Editors and Affiliations

  1. Skin Cancer Center, Hauppauge Dermatology Section, Memorial Sloan Kettering, Veterans Memorial Highway 800, Hauppauge, 11788, New York, USA

    Ashfaq A. Marghoob

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Zalaudek, I. et al. (2012). The Dual Pathway of Nevogenesis. In: Marghoob, A. (eds) Nevogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28397-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-28397-0_4

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