Summary
A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds ofMomordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells (Barbieri et al., 1980b).
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Licastro, F., Franceschi, C., Barbieri, L. et al. Toxicity ofMomordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes. Virchows Archiv B Cell Pathol 33, 257–265 (1980). https://doi.org/10.1007/BF02899186
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DOI: https://doi.org/10.1007/BF02899186