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Comparative toxicology of borates

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Abstract

Inorganic borates, including boric acid, Na, ammonium, K, and Zn borates generally display low acute toxicity orally, dermally, and by inhalation. They are either not irritant or mild skin and eye irritants. Exceptions owing to physiochemical properties do occur.

Longer-term toxicological studies have been reported mainly on boric acid or borax where the properties are generally similar on an equivalent boron (B) basis. The critical effects in several species are male reproductive toxicity and developmental toxicity. The doses that cause these effects are far higher than any levels to which the human population could be exposed. Humans would need to consume daily some 3.3 g of boric acid (or 5.0 g borax) to ingest the same dose level as the lowest animal NOAEL. No effects on fertility were seen in a population of workers exposed to borates or to a population exposed to high environmental borate levels.

There is remarkable similarity in the toxicological effects of boric acid and borax across different species. Other inorganic borates that simply dissociate to boric acid are expected to display similar toxicity, whereas those that do not dissociate simply to boric acid may display a different toxicological profile.

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References

  1. B. D. Culver, R. G. Smith, R. J. Brotherton, P. L. Strong, and T. M. Gray, Boron, inPatty’s Industrial Hygiene and Toxicology, 4th ed., vol. 2F, G. D. Clayton and F. E. Clayton, eds., John Wiley, New York, pp. 4411–4448 (1994).

    Google Scholar 

  2. European Centre for Ecotoxicology and Toxicology of Chemicals, Toxicology and reproductive toxicity of some inorganic borates and risk assessment for man, Technical Report No. 63 (1995).

  3. F. J. Murray, A human health risk assessment of boron (boric acid and borax) in drinking water,Regul. Toxicol. Pharmacol. 22, 221–230 (1995).

    Article  PubMed  CAS  Google Scholar 

  4. J. A. Moore, and an Expert Scientific Committee, Assessment of boric acid and borax using the IEHR evaluative process for assessing human development and reproductive toxicity of agents,Reprod. Toxicol. 11, 123–160 (1997).

    Article  PubMed  CAS  Google Scholar 

  5. S. A. Hubbard and F. M. Sullivan, Toxicological effects of inorganic boron compounds in animals: A review of the literature,J. Trace Elements Exp. Med. 9, 165–173 (1996).

    Article  CAS  Google Scholar 

  6. F. J. Murray,Biol. Trace Elements Res. 66, 331–342 (1999).

    Article  Google Scholar 

  7. J. H. Draize and E. A. Kelley, The urinary excretion of boric acid preparations following oral administration and topical applications to intact and damaged skin of rabbits,Toxicol. Appl. Pharmacol. 1, 267–276 (1959).

    Article  CAS  Google Scholar 

  8. C. Job, Absorption and excretion of orally administered boron,Z. Angew Bader-Klimaheilkunde 20, 137–142 (1973).

    Google Scholar 

  9. T. F. Brown, M. E. McCormick, D. R. Morris, and L. K. Zeringue, Effects of dietary boron on mineral balance in sheep,Nutr. Res. 9, 503–512 (1989).

    Article  CAS  Google Scholar 

  10. W. W. Ku, R. E. Chapin, R. F. Moseman, R. E. Brink, K. D. Pierce, and K. Y. Adams, Tissue disposition of boron in male Fischer rats,Toxicol. Appl. Pharmacol. 111, 145–151 (1991).

    Article  PubMed  CAS  Google Scholar 

  11. J. S. Schou, J. A. Jansen, and B. Aggerbeck, Human pharmacokinetics and safety of boric acid,Arch. Toxicol. 7, 232–235 (1984).

    Article  CAS  Google Scholar 

  12. W. W. Ku, R. E. Chapin, R. N. Wine, and B. C. Gladen, Testicular toxicity of boric acid (BA): Relationship of dose to lesion development and recovery in the F344 rat,Reprod. Toxicol. 7, 305–319 (1993).

    Article  PubMed  CAS  Google Scholar 

  13. J. A. Jansen, J. Anderson, and J. S. Schou, Boric acid single dose pharmacokinetics after intravenous administration to man,Arch. Toxicol. 55, 64–67 (1984).

    Article  PubMed  CAS  Google Scholar 

  14. T. L. Litovitz, W. Klein-Schwartz, G. M. Oderda, and B. F. Schmitz, Clinical manifestations of toxicity in a series of 784 boric acid ingestions,Am. J. Emerg. Med. 6, 209–213 (1988).

    Article  PubMed  CAS  Google Scholar 

  15. B. Friis-Hansen, B. Aggerbeck, and J. A. Jansen, Unaffected blood boron levels in new-born infants treated with a boric acid ointment,Food. Chem. Toxicol. 20, 451–454 (1982).

    Article  PubMed  CAS  Google Scholar 

  16. K. H. Beyer, W. F. Bergfeld, W. O. Berndt, R. K. Boutwell, W. W. Carlton, D. K. Hoffmann, et al., FDA Cosmetic Ingredient Review Expert Panel, Final report on the safety assessment of sodium borate and boric acid,J. Am. Coll. Toxicol. 2, 87–125 (1983).

    Article  CAS  Google Scholar 

  17. H. Maibach, this vol.

  18. G. H. Nielsen, Percutaneous absorption of boric acid form boron-containing preparations in rats,Acta Pharmacol. Toxicol. 28, 413–424 (1970).

    Article  CAS  Google Scholar 

  19. A. J. Vignec and R. Ellis, Inabsorbability of boric acid in infant powder,Am. J. Dis. Child 88, 72–80 (1954).

    CAS  Google Scholar 

  20. G. Stüttgen, T. Siebel, and B. Aggerbeck, Absorption of boric acid through human skin depending on the type of vehicle,Arch. Dermatol. Res. 272, 21–29 (1982).

    Article  PubMed  Google Scholar 

  21. R. J. Weir and R. S. Fisher, Toxicological studies on borax and boric acid,Toxicol. Appl. Pharmacol. 23, 351–364 (1972).

    Article  PubMed  CAS  Google Scholar 

  22. C. C. Pfeiffer, L. F. Hallman, and I. Gersh, Boric acid ointment. A study of possible intoxication in the treatment of burns,J. Am. Med. Assoc. 128, 266–274 (1945).

    Article  CAS  Google Scholar 

  23. E. L. Reagan and P. L. Becci, Acute oral LD50 study of 20 mule team lot no. USB-12-84 sodium tetraborate pentahydrate in New Zealand white rabbits, Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  24. S. M. Denton, Anhydrous boric acid. Acute oral study in the rat. Corning Hazleton (Europe), Harrogate, N Yorkshire, HG3 1PY, Study No. 1341/9-1032 and 1341—1032. Unpublished Report to Borax Europe Limited (1996).

  25. S. M. Denton,Dehybor anhydrous Borax. Acute oral study in the rat. Corning Hazleton (Europe), Harrogate, N Yorkshire, HG3 1PY, Study. No 1341–1032 and 1341/6-1032. Unpublished Report to Borax Europe Limited (1996).

  26. S. M. Denton, Sodium metaborate 4-mol. Acute oral study in the rat. Corning Hazleton (Europe), Harrogate, N Yorkshire, HG3 1PY, Study No. 1341/5-1032 and 1341/8-1032. Unpublished Report to Borax Europe Limited (1996).

  27. R. L. Doyle, Acute oral administration of 8-mol sodium metaborate to rats. Study. No N-118. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to US Borax (1963).

    Google Scholar 

  28. R. M. Chesbro, Letter from Bio-Research Laboratories, Berkley, CA. Oral toxicity and ocular irritation studies on a number of borates. Unpublished report to U.S. Borax (1956).

  29. M. J. Shipp, C. F. Folk, and J. A. Young, Acute oral toxicity study of TS-7504-14-1 potassium tetraborate granular, Study No. 75-550-21. International Bio-Research, Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1975).

    Google Scholar 

  30. R. L. Doyle, Acute oral toxicity in rabbits of disodium octaborate tetrahydrate. Study No. 88-3197-21 Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  31. C. Daniels, M. J. Thomas, and R. H. Teske, Acute toxicity and irritation studies on zinc borate 2335. Report T-298. Hill Top Research Inc. Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1969).

    Google Scholar 

  32. D. R. Cerven, Zinc Borate 4.1.1. Single Dose Oral Toxicity in Rats/LD50. Study No. MB 92-1203 AMB Research Laboratories Ind., Spinnerstown, PA 18968. Unpublished report to U.S. Borax Inc. (1992).

    Google Scholar 

  33. J. Momma, K. TakActa, Y. Suzuki, and M. Tobe, Acute oral toxicity and ocular irritation of chemicals in bleaching agents,J. Food Hygienic Soc. Jpn. 27, 553–560 (1986).

    Article  CAS  Google Scholar 

  34. D. B. Sisk, B. M. Colvin, A. Merrill, K. Bondari, and J. M. Bowen, Experimental acute inorganic toxicosis in the goat: effects on serum chemistry and CSF biogenic amines,Vet. Hum. Toxicol. 32, 205–211 (1990).

    PubMed  CAS  Google Scholar 

  35. D. B. Sisk, B. M. Colvin, and C. R. Bridges, Acute fatal illness in cattle exposed to boron fertilizer,J. Am. Vet. Med. Assoc. 196, 943–945 (1988).

    Google Scholar 

  36. B. D. Culver and S. A. Hubbard, Inorganic boron health effects in humans: An aid to risk assessment and clinical judgement,J. Trace Elements Exp. Med. 9, 175–184 (1996).

    Article  CAS  Google Scholar 

  37. I. Yoshitaka, N. Fujizuka, T. Toshihiko, K. Shimizu, A. Tuchida, S. Yano, et al., A fatal case of acute boric acid poisoning,Clin. Toxicol. 31, 345–352 (1993)

    Article  Google Scholar 

  38. M. D. Baker and S. C. Bogema, Ingestion of boric acid by infants,Am. J. Emerg. Med. 4, 358–361 (1986).

    Article  PubMed  CAS  Google Scholar 

  39. G. Wnorowski, Acute inhalation toxicity limit test on boric acid, Study No. 3311. Product Safety Labs, East Brunswick, NJ 08816. Unpublished report to U.S. Borax (1994).

    Google Scholar 

  40. G. Wnorowski, Acute inhalation toxicity limit on disodium tetraborate decahydrate, Study No. 3309. Product Safety Labs, East Brunswick, NJ 08816, Unpublished report to U.S. Borax (1994).

    Google Scholar 

  41. G. Wnorowski, Acute inhalation toxicity limit on disodium octaborate tetrahydrate, Study No. 3313. Product Safety Labs, East Brunswick, NJ 08816, Unpublished report to U.S. Borax (1994).

    Google Scholar 

  42. G. Wnorowski, Acute inhalation toxicity limit on disodium tetraborate pentahydrate, Study No. 3307. Product Safety Labs, East Brunswick, NJ 08816, Unpublished report to U.S. Borax (1994).

    Google Scholar 

  43. S. Blagden, Firebrake 415: acute inhalation toxicity (nose only) study in the rat. Study No. 801/011. SafePharm Laboratories Ltd., UK. Unpublished Report to Borax Europe Ltd. (1996).

    Google Scholar 

  44. H. E. Stokinger and C. J. Spiegel, Special materials part A. Inhalation-toxicity studies of boron halides and certain fluorinated hydrocarbons, inPharmacology and Toxicology of Uranium Compounds: Chronic Inhalation and Other Studies, C. Voegtlin and H. C. Hodge, eds., McGraw-Hill, New York, pp. 2291–2321 (1953).

    Google Scholar 

  45. E. H. Vernot, J. D. MacEwen, C. C. Haun, and E. R. Kinkead, Acute toxicity and skin corrosion data for some organic and inorganic aqueous solutions,Toxicol. Appl. Pharmacol 42, 417–424 (1977).

    Article  PubMed  CAS  Google Scholar 

  46. E. L. Reagan and P. L. Becci, Acute dermal toxicity study of 20 Mule Team lot no. USB-11-84 sodium tetraborate decahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  47. E. L. Reagan and P. L. Becci, Acute dermal toxicity study of 20 Mule Team lot no. USB-12-84 sodium tetraborate pentahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  48. R. L. Doyle, Acute dermal toxicity in rabbits of disodium octaborate tetrahydrate. Hill Top Biolabs Inc., Miamiville, OH, 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  49. J. J. Kreuzmann, Acute dermal toxicity in rabbits—limit test XPI-187 zinc borate. Study No. 90-4186-21. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1990).

    Google Scholar 

  50. D. L. Cerven, Acute dermal toxicity in rabbits/ LD50 in rabbits. Zinc Borate 4.1.1. MB Research Laboratories Inc., Spinnerstown, PA, 18968. Project No. MB 92-1301 B. Unpublished report to U.S. Borax (1992).

    Google Scholar 

  51. EEC Council Directive 93/35/EEC (14 June 1993) amending for the sixth time Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products. OJ L151, 23.06.93, 32 (1993).

  52. L. Roudabush, C. J. Terhaar, D. W. Fassett, and S. P. Dziuba, Comparative acute effects of some chemicals on the skin of rabbits and Guinea pigs,Toxicol. Appl. Pharmacol. 7, 559–565 (1965).

    Article  PubMed  CAS  Google Scholar 

  53. A. A. Silaev, Experimental determination of the maximum permissible concentration of sodium perborate in workplace air,Gig. Te. Prof. Zabo. 6, 44 (1984).

    Google Scholar 

  54. E. L. Reagan and P. L. Becci, Primary dermal irritation study of 20 Mule Team lot no. USB-11-84 sodium tetraborate decahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  55. E. L. Reagan and P. L. Becci, Primary dermal irritation study of 20 Mule Team lot no. USB-12-84 sodium tetraborate pentahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  56. R. J. Doyle, Primary skin irritation in rabbits of disodium octaborate tetrahydrate. Hill Top Biolabs Inc., Miamiville, OH, 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  57. J. A. Young, and R. L. Doyle, Corrosivity study on a series of ten materials. 73-630-21, Hill Top Research Inc., Cincinnati, OH, 45242. Unpublished report to U.S. Borax (1973).

    Google Scholar 

  58. D. L. Cerven, Primary dermal irritation in albino rabbits. Zinc Borate 4.1.1. MB Research Laboratories Inc., Spinnerstown, PA 18968. Project No: MB 92-1301 C. Unpublished report to U.S. Borax (1992).

    Google Scholar 

  59. J. J. Kreuzmann, Primary skin irritation study in rabbits of: XPI-187 Zinc Borate. Study No. 90-4186-21 Hill Top Biolabs Inc. Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1990).

    Google Scholar 

  60. R. L. Doyle, Primary eye irritation of boric acid. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  61. R. L. Doyle, Eye irritation study without rinsing in rabbits of disodium octaborate tetrahydrate. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  62. R. L. Doyle, Primary eye irritation in rabbits of disodium octaborate tetrahydrate. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  63. D. L. Cerven, Primary eye irritation and/or corrosion in rabbits. Zinc Borate 4.1.1. MB Research Laboratories Inc., Spinnerstown, PA 18968. Project No. MB 92-1301 D. Unpublished report to U.S. Borax (1992).

    Google Scholar 

  64. J. J. Kreuzmann, Primary eye irritation study in rabbits of: XPI-187 Zinc Borate Study No. 90-4186-21. Hill Top Biolabs, Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1990).

    Google Scholar 

  65. E. L. Reagan and P. L. Becci, Primary eye irritation study of 20 mule team lot no. USB-11-84 sodium tetraborate decahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  66. E. L. Reagan and P. L. Becci, Primary eye irritation study of 20 mule team lot no. USB-12-84 sodium tetraborate pentahydrate in New Zealand white rabbits. Food and Drug Research Laboratories Inc., Waverly, NY 14892. Unpublished report to U.S. Borax (1985).

    Google Scholar 

  67. R. L. Doyle, Primary eye irritation of 10 Borax Mol. Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax (1989).

    Google Scholar 

  68. G. Wnorowski, Dermal sensitization test—Buehler method on boric acid, Study No. 3310. Product Safety Labs, East Brunswick, NJ 08816. Unpublished report to U.S. Borax (1994).

    Google Scholar 

  69. G. Wnorowski, Dermal sensitization test—Buehler method on disodium octaborate tetrahydrate, Study No. 3312. Product Safety Labs, East Brunswick, NJ 08816. Unpublished report to U.S. Borax (1994).

    Google Scholar 

  70. G. Wnorowski, Dermal sensitization test—Buehler method on sodium tetraborate decahydrate, Study No. 3308. Product Safety Labs, East Brunswick, NJ 08816. Unpublished report to U.S. Borax (1994).

    Google Scholar 

  71. G. Wnorowski, Dermal sensitization test—Buehler method on sodium tetraborate pentahydrate, Study No. 3306. Product Safety Labs, East Brunswick, NJ 08816. Unpublished report to U.S. Borax (1994).

    Google Scholar 

  72. K. Snell, Firebrake 415: Magnusson & Kligman Study in the Guinea Pig. SafePharm Laboratories Ltd., Derby, UK, Project No. 801/002. Unpublished report to Borax Europe Ltd. (1996).

    Google Scholar 

  73. J. J. Kreuzmann, Delayed Contact Hypersensitisation Study in Guinea Pigs of Firebrake® ZB Zinc Borate 2335. Study No. 90-4038-21 Hill Top Biolabs Inc., Miamiville, OH 45147. Unpublished report to U.S. Borax Inc. (1990).

    Google Scholar 

  74. M. Bruze, E. Hradil, I-L. Eriksohn, B. Gruvberger, and L. Widstrom, Occupational allergic contact dermatitis from alkanolamineborates in metalworking fluids,Contact Dermatitis 32, 24–27 (1995).

    Article  PubMed  CAS  Google Scholar 

  75. D. H. Wegman, E. A. Eisen, X. Hu, S. Woskie, R. G. Smith, and D. H. Garabant, Acute and chronic respiratory effects of sodium borate particulate exposures,Environ. Health Perspectives 102, 119–128 (1994).

    CAS  Google Scholar 

  76. National Toxicology Program: Toxicology and carcinogenesis studies of boric acid (CAS No. 10043-35-3) in B6C3F1 mice. US Department of Health and Human Services, National Institute of Health (Technical Report Series No. 324) (1987).

  77. S. Haworth, T. Lawlor, and K. Mortelmans, Salmonella mutagenicity test results for 250 chemicals,Environ. Mutat. Suppl. 1, 3–142 (1983).

    Google Scholar 

  78. J. R. Landolph, Cytotoxicity and negligible genotoxicity of borax ores to cultured mammalian cells,Am. J. Ind. Med. 7, 31–43 (1985).

    Article  PubMed  CAS  Google Scholar 

  79. J. P. Bakke, Evaluation of the potential of boric acid to induce unscheduled DNA synthesis in thein vitro hepatocyte DNA repair assay using the male F-344 Rat. SRI International, Menlo Park, CA, Study No. 2389-V500-91; and Amendment 1 to the Original Report. Unpublished Report to U.S. Borax (1991).

  80. K. R. Stewart,Salmonella/microsome plate incorporation assay of boric acid. SRI International, Menlo Park, CA, Study No. 2389-A200-91, Unpublished report to U.S. Borax (1991).

    Google Scholar 

  81. K. G. O’Loughlin, Bone marrow erythrocyte micronucleus assay of boric acid in Swiss-Webster mice. SRI International, Menlo Park, CA, Study No. 2389-C400-91, August 1991. Unpublished Report to U.S. Borax (1991).

    Google Scholar 

  82. H. S. Rosenkranz, Sodium hypochlorite and sodium perborate; preferential inhibitors of DNA polymerase deficient bacteria,Mutat. Res. 21, 171–174 (1973).

    Article  PubMed  CAS  Google Scholar 

  83. J. P. Selier, The mutagenic activity of sodium perborate,Mutat. Res. 224, 219–227 (1989).

    Article  Google Scholar 

  84. P. W. Thompson,Firebrake 415: Reverse Mutation Assay “Ames Test” usingSalmonella Typhimurium andEscherichia Coli. SafePharm Laboratories Ltd, Derby, UK. Project No. 801/004. Unpublished report to Borax Europe Ltd. (1996).

    Google Scholar 

  85. G. C. Lavelle and M. Entrup, The Salmonella/Microsomal Assay for Bacterial Mutagenic Activity of Firebrake ZB. Study No 81-0932-21 Hill Top Research Inc. P.O. Box 42501, Cincinnati, OH 45242. Unpublished report to U.S. Borax Inc. (1981).

    Google Scholar 

  86. R. Durward and N. P. Wright,Firebrake 415: Chromosome Aberration test in CHL cellsin vitro. SafePharm Laboratories Ltd, Derby, UK. Project No. 801/005. Unpublished report to Borax Europe Ltd. (1996).

    Google Scholar 

  87. C. T. Walsh, H. H. Sandstead, A. S. Prasad, P. M. Newberne, and P. J. Fraker, Zinc: Health effects and research priorities for the 1990s,Environ. Health Perspectives 102, 5–46 (1994).

    CAS  Google Scholar 

  88. W. Kliegel,BOR in Biologie, Medizin und Pharmazie, Springer-Verlag, Berlin (1980).

    Book  Google Scholar 

  89. A. S. Gordon, J. S. Prichard, and M. H. Freedman, Seizure disorders and anemia associated with chronic borax intoxication,C.M.A.J. 108, 719–724 (1973).

    CAS  Google Scholar 

  90. K. O’Sullivan and M. Taylor, Chronic boric acid poisoning in infants,Arch. Dis. Childhood 58, 737–749 (1983).

    Article  Google Scholar 

  91. R. E. Linder, L. F. Strader, and G. L. Rehnberg, Effect of acute exposure to boric acid on the male reproductive system of the rat,J. Toxicol. Environ. Health 31, 133–146 (1990).

    Article  PubMed  CAS  Google Scholar 

  92. H. Bouissou and R. Castagnol, Action de l’acide borique dur le testicule de rat. Archives des Maladies Professionelles de Medecin du Travail et de Sécurité Social, T286, 293–306 (1965).

  93. I. P. Lee, R. J. Sherins, and R. L. Dixon, Evidence for induction of germinal aplasia in male rats by environmental exposure to boron,Toxicol. Appl. Pharmacol. 45, 577–590 (1978).

    Article  PubMed  CAS  Google Scholar 

  94. P. A. Fail, J. D. George, J. C. Seely, T. B. Grizzle, and J. J. Heindel, Reproductive toxicity of boric acid in Swiss (CD-1) mice: assessment using the continuous breeding protocol,Fundam. Appl. Toxicol. 17, 225–239 (1991).

    Article  PubMed  CAS  Google Scholar 

  95. Anonymous, Sodium perborate tetrahydrate. A four-week oral toxicity study after repeated administration in rats. Study No. 687666. Unpublished report to Degussa AG, Hanau, Germany (1989).

  96. M. D. Whorton, J. L. Haas, L. Trent, and O. Wong, Reproductive effects of sodium borates on male employees: birth rate assessment,Occup. Environ. Med. 51, 761–767 (1994).

    Article  PubMed  CAS  Google Scholar 

  97. B. S. Sayli,Biol. Trace Element Res. 66, 409–422 (1999).

    Article  Google Scholar 

  98. C. J. Price, P. L. Strong, M. C. Marr, C. B. Myers, and F. J. Murray, Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation,Fundam. Appl. Toxicol. 32, 179–193 (1996).

    Article  PubMed  CAS  Google Scholar 

  99. J. J. Heindel, C. J. Price, E. A. Field, M. C. Marr, C. B. Myers, R. E. Morrissey, et al., Developmental toxicity of boric acid in mice and rats,Fundam. Appl. Toxicol. 18, 266–272 (1992).

    Article  PubMed  CAS  Google Scholar 

  100. C. J. Price, M. C. Marr, C. B. Myers, J. J. Heindel, and B. A. Schwetz, Final report on the developmental toxicity of boric acid (CAS No. 10043-35-3) in New Zealand white rabbits, NIEHS/NTP Order No. PB92-129550 (1991).

  101. R. Bussi, Sodium perborate tetrahydrate: Teratogenesis study in rats by oral route, RBM SpA, Torino, Italy. Unpublished report to Conseil European de l’Industrie Chimique (CEFIC) (1995).

    Google Scholar 

  102. D. Fort et al.,Biol. Trace Element Res. 66, 237–260 (1999).

    Article  Google Scholar 

  103. R. I. Rowe, C. Bouzan, Si Nabili, and C. Deckhert,Biol. Trace Element Res. 66, 261–270 (1999).

    Article  Google Scholar 

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    Susan A. Hubbard

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Hubbard, S.A. Comparative toxicology of borates. Biol Trace Elem Res 66, 343–357 (1998). https://doi.org/10.1007/BF02783147

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