Abstract
Eighth young adult male volunteers with a basic (alimentary) plasma boric acid concentration of <0.10–0.46 mg/l were given a single dose of boric acid (562–611 mg) by 20 min IV infusion. The plasma concentration curves, followed for 3 days, best fitted a three-compartment open model, although two subjects had to be left out due to inconstant basal plasma concentration values or failure to fit to the three-compartment model. The 120 h urinary excretion was 98.7±9.1% of dose, Cltot 54.6±8.0 ml/min/1.73 m2, t1/2β 21.0±4.9 h and distribution volumes V1, V2, and V3: 0.251±0.099, 0.456±0.067 and 0.340±0.128 l/kg.
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References
Ellis GH, Zook EG, Baudisch O (1949) Colometric determination of boron using 1,1′-dianthrimide. Anal Chem 21: 1345
Farr LE, Konikowski T (1963) The Renal Clearance of Sodium Pentaborate in Mice and Men. Clin Chem 9: 717
Friis-Hansen B, Aggerbeck B, Jansen JA (1982) Unaffected blood boron levels in newborn infants treated with a boric acid ointment. Fd Chem Toxic 20: 451
Jansen JA, Schou JS, Aggerbeck B (1984) Gastrointestinal absorption and in vitro release of boric acid, from water-emulsifying ointments. Fd Chem Toxic 22: 49–53
Kaczmarcyk A, Meser JR, Perice CE (1971) Rapid method for determination of boron in biological materials. Anal Chem 43: 271
Stüttgen G, Siebel T, Aggerbeck B (1982) Absorption of boric acid through human skin depending on the type of vehicle. Arch Derm Res 272: 21
West ES, Todd WR (1963) Textbook of biochemistry. New York: The Macmillan Company
Yamaoka K, Nakagawa T, Uno T (1978) Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm VI: 165–177
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Jansen, J.A., Andersen, J. & Schou, J.S. Boric acid single dose pharmacokinetics after intravenous administration to man. Arch Toxicol 55, 64–67 (1984). https://doi.org/10.1007/BF00316588
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DOI: https://doi.org/10.1007/BF00316588