Abstract
Using an in vitro technique it has been demonstrated that water-emulsifying and hydrophobic ointments containing boric acid liberate only minute amounts (1–6%) within 24h compared with the nearly total liberation from a jelly. When an amount of boric acid containing ointment is swallowed, the absorption is only slightly delayed compared with a similar intake when dissolved in water, and in both cases nearly total excretion is found in the urine within 96 h. The halflife (t 1/2β ) is 21h (mean, 7 adult men). The pharmacokinetics rule out the risk of cumulative poisoning with topical preparations containing low amounts of boric acid. The use of water-emulsifying ointments containing up to 3% boric acid should be safe, even for repeated daily use in the napkin region.
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References
Friis-Hansen B, Aggerbeck B, Jansen JAa (1982) Unaffected blood boron levels in newborn infants treated with boric acid ointment. Food Chem Toxicol 20: 451–454
Godlee RJ (1873) On the antiseptic system. Lancet 1: 694–695
Mutimer MN, Riffkin C, Hill JA, Glickman ME, Cyr GN (1956) Modern ointment base technology II. Comparative evaluation of bases. J Am Pharm Assoc 45: 212–218
Stüttgen G, Siebel T, Aggerbeck B (1982) Absorption of boric acid through human skin depending on the type of vehicle. Arch Dermatol Res 272: 21–29
Yamaoka K, Nakagawa T, Uno T (1978) Application of Akaike’s information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokin et Biopharm 4: 165–177
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© 1984 Springer-Verlag
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Schou, J.S., Jansen, J.A., Aggerbeck, B. (1984). Human Pharmacokinetics and Safety of Boric Acid. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_32
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DOI: https://doi.org/10.1007/978-3-642-69132-4_32
Publisher Name: Springer, Berlin, Heidelberg
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