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CD26 (dipeptidyl aminopeptidase IV) expression in normal and diseased human thyroid glands

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Abstract

The objective of the present study was to investigate CD26 (dipeptidyl aminopeptidase IV) expression in normal and diseased thyroids and its relation to differentiation and cell proliferation. CD 26 was also evaluated as a possible marker of malignancy in thyroid neoplasias.

A total of 38 normal thyroids and 117 diseased thyroids (neoplastic and non-neoplastic) were evaluated. CD26 and thyroglobulin (Tg) expression was determined by analyzing at least 200 cells/specimen. A minimum of 500 cells/specimen were counted to calculate the MIB-1-positive cell rate expressed as a percentage of total nucleated epithelial cells.

CD26 expression was absent in all thyroids from fetuses and children. Among the adults, 7.1% had CD26 expression only in oncocytic metaplastic areas. In 3 of the 7 elderly subjects, CD26 expression was present in 0.2–90% of epithelial cells. CD26 expression was observed in all diseased thyroids. Since this enzyme is also expressed in benign conditions, it is not useful as a marker of malignancy.

There was no relationship between CD26 and Tg expression. The MIB-1-positive cell rate was found to be low for all kinds of thyroid tissues, and when the cell proliferation rate was analyzed according to CD26 expression, a greater cell proliferation rate was found in CD26-positive differentiated (follicular and papillary) carcinomas than in CD26-negative carcinomas. These results demonstrate that expression of this enzyme is related to the proliferative activity of follicular cells.

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Authors and Affiliations

  1. Discipline of Systemic Pathology, Triangulo Mineiro Medical School, Uberaba Minas Gerais, Brazil

    Marcus A. Lima MD, PhD & Valéria A. Gontijo MD

  2. Unit of Molecular Pathology, Institute of Pathology and Molecular Immunology of Porto University, Portugal

    Fernando C. L. Schmitt MD, PhD

Authors
  1. Marcus A. Lima MD, PhD
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  2. Valéria A. Gontijo MD
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  3. Fernando C. L. Schmitt MD, PhD
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Correspondence to Marcus A. Lima MD, PhD.

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Lima, M.A., Gontijo, V.A. & Schmitt, F.C.L. CD26 (dipeptidyl aminopeptidase IV) expression in normal and diseased human thyroid glands. Endocr Pathol 9, 43–52 (1998). https://doi.org/10.1007/BF02739951

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