Summary
Thein vitro basal insulin release and45Ca2+ uptake by rat islets of Langerhans remain unaffected by the animal’s age. However, whenAgaricus bisporus lectin PHA-B is added to the medium, there is a significant stimulation of basal insulin secretion and45Ca2+ uptake. The islets isolated from younger rats are more sensitive toA. bisporus PHA-B stimulation and register 1.5-fold and 3-fold more increases of insulin release and45Ca2+ uptake respectively as compared to islets isolated from 12-month-old rats. Age-related conformational changes in the B-cell membrane are suggested as a possible explanation for the above observation.
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CDRI Communication No. 3428
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Ahmad, N., Khan, M.M., Rastogi, A.K. et al. Effect of age onAgaricus bisporus PHA-B stimulated insulin release and45Ca2+ uptakein vitro by islets of langerhans. Acta diabet. lat 21, 349–355 (1984). https://doi.org/10.1007/BF02582088
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DOI: https://doi.org/10.1007/BF02582088