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Carcinogenesis tests of nitroso-N-methylpiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, nitrosoisonipecotic acid and nitrosomethoxymethylamine in rats

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Summary

Four nitrosamines; nitroso-N-methylpiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, nitrosoisonipecotic acid and nitrosomethoxymethylamine, closely related in structure to potent carcinogens, were fed chronically to rats in drinking water for one year. No toxic effects leading to life shortening were observed. There was no significant incidence of any malignant tumor other than the endocrine tumors normally found in untreated animals of our colony. This indicated that the small changes in structure represented by these compounds were sufficient to reduce greatly, or eliminate, the carcinogenic action.

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Authors and Affiliations

  1. Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, 38730, Oak Ridge, Tennessee, USA

    W. Lijinsky & H. W. Taylor

  2. Frederick Cancer Research Center, 21701, Frederick, Maryland, USA

    W. Lijinsky

  3. Department of Pathology and Parasitology, School of Medicine, Auburn University, 36830, Auburn, Alabama, USA

    H. W. Taylor

Authors
  1. W. Lijinsky
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  2. H. W. Taylor
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Supported by the Carcinogenesis Program of the National Cancer Institute and the Energy Research and Development Administration under contract with Union Carbide Corporation

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Lijinsky, W., Taylor, H.W. Carcinogenesis tests of nitroso-N-methylpiperazine, 2,3,5,6-tetramethyldinitrosopiperazine, nitrosoisonipecotic acid and nitrosomethoxymethylamine in rats. Z. Krebsforsch. 89, 31–36 (1977). https://doi.org/10.1007/BF02571686

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  • DOI: https://doi.org/10.1007/BF02571686

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