Skip to main content
SpringerLink
Log in

The effects of 17β-estradiol and progestagen on trabecular bone remodeling in oophorectomized dogs

  • Laboratory Investigations
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Summary

We present the results of the static and dynamic histomorphometric analyses of parameter measurements of trabecular bone remodeling activity in nonoophorectomized, untreated oophorectomized, 17β-estradiol-supplemented oophorectomized, as well as progestagen-supplemented oophorectomized beagle dams. If the spayed beagle dam can be considered a model in which one may equivalate bone changes occurring in the ovarian hormone-deficient human female, we reach the following conclusions: (1) The presence or absence of quasi-physiological levels of single ovarian hormones do affect the status of trabecular bone. (2) The evidence indicates that the presence or absence of individual ovarian hormones do not have a simple effect on trabecular bone remodeling. Apart from affecting the numbers of new bone remodeling units (BMUs) that are initiated in unit time, their effect is seen to be extended to the working efficiency of existing osteoclasts and osteoblasts. The effect is also manifest on the total amount of work performed by the collections of osteoclasts and osteoblasts that provide the respective resorptive and formation phases of the BMU. (3) Finally, we are led to believe that there may be a close interdependence both in physiological activity and therapeutic response between the four active bone envelopes. Such protean effects have hitherto not received their due consideration from researchers in this field.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ivey JL, Baylink DJ (1981) Post-menopausal osteoporosis: proposed roles of defective coupling and estrogen deficiency. Met Bone Dis Rel Res 3:3–8

    Article  Google Scholar 

  2. Recker RR (1981) Continuous treatment of osteoporosis: current status. Orthop Clin North Am 12:611–627

    PubMed  CAS  Google Scholar 

  3. Riggs BL, Melton III LJ, Wahner HW (1983) Heterogeneity of involutional osteoporosis: evidence for two distinct osteoporosis syndromes. In: Frame B, Potts JT, Jr (eds) Clinical disorders of bone & mineral metabolism. Excerpta Medica, Amsterdam, pp 337–342

    Google Scholar 

  4. Christiansen C (1984) Prophylactic treatment for age-related bone loss in woman. Abstracts, Copenhagen Int Symp Osteoporosis, p 128

  5. Ettinger B, Genant HK (1984) Long-term estrogen therapy prevents fractures and preserves bone mass. Abstracts, Copenhagen Int Symp Osteoporosis, p 124

  6. Lindsay R (1984) Treatment of osteoporosis with antiresorptive drugs—estrogen, progestins and calcium. Abstracts, Copenhagen Int Symp Osteoporosis, p 123

  7. Eisinger J, Laponche AM, Ouzniche J (1984) Trabecular bone mass in post-menopausal osteoporosis: effects of various treatments. Abstracts, Copenhagen Int Symp Osteoporosis, p 137

  8. Kanis JA (1984) Treatment of osteoporotic fracture. Lancet 1:27–33

    Article  PubMed  CAS  Google Scholar 

  9. Lindsay R, Hart DM, MacLean A, Garwood J, Aitken JM, Clark AC, Coutts JRT (1978) Phathogenesis and prevention of post-menopausal osteoporosis. In: Cooke ID (ed) The role of estrogen/progestagen in the management of the menopause. University Park Press, Baltimore, Maryland, pp 9–25

    Google Scholar 

  10. Anderson C (1982) Handbook for the examination of bone. CRC Press Inc, Boca Raton, Florida, pp 57–58, 93–109

    Google Scholar 

  11. Manaka RC, Malluche HH (1981) A program package for quantitative analysis of histologic structure and remodeling dynamics of bone. Comput Programs Biomed 13:191–202

    Article  PubMed  CAS  Google Scholar 

  12. Malluche HH, Sherman D, Meyer W, Massry SC (1982) A new semi-automatic method for quantitative static and dynamic bone histology. Calcif Tissue Int 34:439–448

    Article  PubMed  CAS  Google Scholar 

  13. Frost HM (1976) Histomorphometry of trabecular bone. In: Meunier PJ (ed) Bone histomorphometry, 2nd Int Workshop, pp 361–370

  14. Frost HM (1981) Resting seams: “on” and “off” in lamellar bone forming centers. In: Jee WSS and Parfitt AM (eds) Bone histomorphometry, 3rd Int Workshop, pp 167–170

  15. Colton T (1974) Statistics in medicine. Little, Brown & Co, Boston, pp 139–142

  16. High WB, Capen CC, Black HE (1981) Histomorphometric evaluation of the effects of intermittent 1,25-dihydroxycholecalciferol administration on cortical bone remodeling in adult dogs. Am J Pathol 104:41–49

    PubMed  CAS  Google Scholar 

  17. Kimmel DB, Jee WSS (1982), Quantitative histological study of bone turnover in young adult beagles. Anat Rec 203:31–45

    Article  PubMed  CAS  Google Scholar 

  18. Martin RK, Albright JP, Jee WSS, Taylor GN, Clarke WR (1981) Bone loss in the Beagle tibia: influence of age, weight and sex. Calif Tissue Int 33:233–238

    Article  CAS  Google Scholar 

  19. Frost HM (1969) Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3:211–237

    Article  PubMed  CAS  Google Scholar 

  20. Andersen AC (1970) The beagle as an experimental dog. Iowa State University Press, Ames, Iowa pp 31–33, 279–280

    Google Scholar 

  21. Heaney RP, Recker RR, Saville PD (1978) Menopausal changes in bone remodeling. J Lab Clin Med 92:964–970

    PubMed  CAS  Google Scholar 

  22. Heaney RP (1979) Calcium metabolic changes at menopause. In: Barzel US (ed) Osteoporosis II. Grune and Stratton, New York, New York, pp 101–109

    Google Scholar 

  23. Baron R, Vignery A, Lang R (1981) Reversal phase and osteopenia: defective coupling of resorption to formation in the pathogenesis of osteoporosis. In: DeLuca HF, Frost HM, Jee WSS, Johnston CC, Jr, Parfitt AM (eds) Osteoporosis: recent advances in pathogenesis and treatment. University Park Press, Baltimore, Maryland pp 311–320

    Google Scholar 

  24. Jaworski ZFG (1984) Coupling of bone formation to bone resorption: a broader view. Calcif Tissue Int 36:531–535

    Article  PubMed  CAS  Google Scholar 

  25. Kanis JA (1985) Osteoporosis. In: Butler WT (ed) Chemistry and biology of mineralized tissue. Ebsco Media Inc, Birmingham Alabama pp 398–407

    Google Scholar 

  26. Courpron P, Lepine P, Arlot M, Lips P, Meunier PJ (1980) Mechanisms underlying the reduction with age of the mean wall thickness of trabecular basic structure unit (BSU) in human iliac bone. Metab Bone Dis Rel Res 25:323–329

    Google Scholar 

  27. Meunier PJ, Courpron P (1976) Iliac trabecular bone in 236 controls. In: Jaworski ZFG (ed) Proc Workshop on Bone Histomorphometry, University of Ottawa Press, Ottawa

    Google Scholar 

  28. Snow GR, Cook MA, Anderson C (1984) Oophorectomy and cortical bone remodeling in the Beagle. Calcif Tissue Int 36:586–590

    Article  PubMed  CAS  Google Scholar 

  29. Snow GR, Anderson C (1985) The effects of continuous progestagen treatment of cortical bone remodeling in the Beagle. Caclif Tissue Int 37:282–286

    CAS  Google Scholar 

  30. Snow GR, Anderson C (in press) The effects of continuous estradiol therapy on cortical bone remodeling in the spayed Beagle. Calcif Tissue Int

  31. Karambolova KK, Snow GR, Anderson C (1985) Differences in periosteal and cortico-endosteal bone envelope activities in spayed and intact Beagles: a histomorphometric study. Calcif Tissue Int 37:665–668

    PubMed  CAS  Google Scholar 

  32. Karambolova KK, Snow GR, Anderson C (in press) Surface activity on the periosteal and cortico-endosteal envelopes following continuous progestagen supplementation in spayed Beagles. Calcif Tissues Int

  33. Frost HM (1983) Bone histomorphometry: analysis of trabecular bone dynamics. In Recker RR (ed) Bone histomorphometry: techniques and interpretation. CRC Press, Boca Raton, Florida pp 109–131

    Google Scholar 

  34. Eriksen EF, Melsen F, Mosekilde L (1984) Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals. Metab Bone Dis Rel Res 5:235–242

    Article  CAS  Google Scholar 

  35. Eriksen EF, Gunderson F, Melsen F, Mosekilde L (1984) Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing kinetic model for matrix and mineral apposition. Metab Bone Dis Rel Res 5:243–252

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Health Sciences Center, University of Western Ontario, N6A 5C1, London, Ontario, Canada

    Gillian R. Snow & Colin Anderson

Authors
  1. Gillian R. Snow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Colin Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Snow, G.R., Anderson, C. The effects of 17β-estradiol and progestagen on trabecular bone remodeling in oophorectomized dogs. Calcif Tissue Int 39, 198–205 (1986). https://doi.org/10.1007/BF02555118

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02555118

Key words

Search

Navigation