Summary
Cortical bone remodeling measurements were carried out on the ribs of 6 spayed and five control Beagle dams which had been subjected to a period of observation equal to more than one sigma of cortical bone remodeling activity. The results of the measurements of static and dynamic parameters indicate that the lack of ovarian hormones does not produce a major alteration in the rates of cortical bone remodeling, but does result in an increase in the number of resorption spaces per mm2 of cortical bone without altering the parameters of bone function. This latter fact supports the hypothesis that decreased levels of circulatory ovarian hormones may influence the duration of the resorption activity as well as possibly uncoupling the resorption/formation (R/F) mechanism of the bone remodeling unit.
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References
Anderson C (1982) Handbook for the examination of bone. C.R.C. Press Inc, Florida, pp 57–58, 93–109
Villaneuva AB (1980) Bone. In: Sheehan DC, Hrapchak BB (eds) Theory and practice of histotechnology. C.V. Mosby, London
Colton T (1974) Statistics in medicine. Little, Brown & Company, Boston, pp 138–143
Chakraborty PK, Panko WB, Fletcher WS (1980) Serum hormone concentrations and their relationships to sexual behaviour at the first and second estrous cycles of the Labrador bitch. Biol Reprod 22:227–232
Albright F (1941) Post-menopausal osteoporosis: its clinical features. JAMA 116:2465–2474
Urist MR, Budy AM, McLean FC (1948) Species differences in the reaction of the mammalian skeleton to estrogens. Proc Soc Exp Biol 69:324–326
Recker RR. Effect of estrogens and calcium carbonate on bone loss in post-menopausal women. Ann Int Med 87:649–655
Frost HM (1964) Mathematical elements of lamellar bone remodeling. Charles C. Thomas, Springfield, Ill, p 122
Martin RK, Albright JP, Jee WSS, Taylor GN, Clarke WR (1981) Bone loss in the Beagle tibia: influence of age, weight and sex. Calcif Tissue Int 33(3):233–238
Frost HM (1969) Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3:211–237
Anderson C, Danylchuk KD (1979) Age-related variations in cortical bone-remodeling measurements in male Beagles 10 to 26 months of age. Am J Vet Res 40(6):869–872
High WB, Capen CC, Black HE (1981) Histomorphometric evaluation of the effects of intermittent 1,25-dihydroxycholecalciferol administration on cortical bone remodeling in adult dogs. AJP 104(1):41–49
Avioli LV (1978) The biochemical and skeletal heterogeneity of post-menopausal osteoporosis. In: Barzel US (ed) Osteoporosis II, pp 49–64
Frost HM (1973) Bone remodeling and its relationship to metabolic bone diseases. Charles C. Thomas, Springfield, Ill, pp 54–114
Andersen AC, Good LS (1970) The Beagle as an experimental dog. The Iowa State University Press, Ames, Iowa, pp 35–38
Baron R, Vignery A, Lang R (1981) Reversal phase and osteopenia: defective coupling of resorption to formation in the pathogenesis of osteoporosis. In: D; DeLuca HF et al (eds) Osteoporosis: recent advances in pathogenesis and treatment, pp 311–320
Ivey JL, Baylink DJ (1981) Post-menopausal osteoporosis: proposed roles of defective coupling and estrogen deficiency. Met Bone Dis & Rel Res 3:3–8
Faugere MC, Malluche HHY, Okamoto S, DeLuca HF (1983) 1,25(OH)2D3 reverses bone loss due to oophorectomy. Calcif Tissue Int 35 (suppl):Abstract 39
Riggs BL, Gallagher JC, DeLuca HF (1978) A syndrome of osteoporosis, increased serum immunoreactive parathyroid hormone, and inappropriately low serum 1,25-dihydroxy-vitamin D. Mayo Clin Proc 53:701
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Snow, G.R., Cook, M.A. & Anderson, C. Oophorectomy and cortical bone remodeling in the beagle. Calcif Tissue Int 36, 586–590 (1984). https://doi.org/10.1007/BF02405371
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DOI: https://doi.org/10.1007/BF02405371