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Brain uptake of halogenated products of D-glucal

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of18F-2-deoxy-2-fluoro-D-glucose and18F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.

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Authors and Affiliations

  1. Laboratory for Radiopharmaceutical Chemistry, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, 105, Tokyo, Japan

    Y. Homma, Y. Murase & M. Ishii

Authors
  1. Y. Homma
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  2. Y. Murase
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  3. M. Ishii
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Homma, Y., Murase, Y. & Ishii, M. Brain uptake of halogenated products of D-glucal. J. Radioanal. Chem. 76, 283–288 (1983). https://doi.org/10.1007/BF02517592

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  • DOI: https://doi.org/10.1007/BF02517592

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