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Does trimetazidine act as antioxidant?

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Trimetazidine is 2-fold inferior to probucol in antioxidant activity measured using the model of copper-induced free radical oxidation of human plasma lipoproteins. EPR-spectroscopy shows that trimetazidine forms no free-radical intermediates in the presence of generated lipid alkoxyl or hydroxyl radicals, while probucol under these conditions forms phenoxyl radicals. Trimetazidine does not interact with superoxide radicals generated in the xanthinexanthine oxidase system, since it does not inhibit reduction of tetrazolium nitroblue. However, indirect effect of trimetazidine on free radical oxidation cannot be excludedin vivo.

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Authors and Affiliations

  1. Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow

    A. K. Tikhaze, V. Z. Lankin, S. V. Kolycheva, G. G. Konovalova, K. B. Shumaev, A. I. Kozachenko, S. M. Gurevich, E. A. Zharova & L. D. Smirnov

Authors
  1. A. K. Tikhaze
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  2. V. Z. Lankin
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  3. S. V. Kolycheva
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  4. G. G. Konovalova
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  5. K. B. Shumaev
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  6. A. I. Kozachenko
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  7. S. M. Gurevich
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  8. E. A. Zharova
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  9. L. D. Smirnov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 551–554, November, 1998

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Tikhaze, A.K., Lankin, V.Z., Kolycheva, S.V. et al. Does trimetazidine act as antioxidant?. Bull Exp Biol Med 126, 1132–1134 (1998). https://doi.org/10.1007/BF02447254

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  • DOI: https://doi.org/10.1007/BF02447254

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