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Zur Feinstruktur der sog. Membrana limitans externa der menschlichen Retina

The fine structure of the so-called outer limiting membrane in the human retina

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Summary

The so-called outer limiting membrane of the retina is not a true membrane. By electron microscopy it appears as a layer of intracellular cytoplasmic densities. They should be considered as Zonulae adhaerentes. In this area the intercellular gap is 200 Å wide as opposed to a normal value of 150 Å. Zonulae adhaerentes are a special type of interceullular junction, which have a primarily mechanical function. They create a solid connection between the basal part of the inner segments of the photoreceptors and the surrounding Müller cells. In addition, they provide connections between several adjoining Müller cells.

Zusammenfassung

Die sog. Membrane limitans externa der Retina ist keine wirkliche Membran. Sie erweist sich im Elektronenmikroskop als eine Lage intracellulärer cytoplasmatischer Verdichtungen, die alsZonulae adhaerentes anzusprechen sind. In diesem Bereich ist der intercelluläre Spalt auf 200 Å verbreitert. Die Zonulae adhaerentes haben eine primär mechanische Funktion, indem sie die Basis der Innenglieder der Photoreceptoren mit den umgebenden Müllerschen Stützzellen sowie benachbarte Müllersche Stützzellen untereinander verbinden.

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Literatur

  • Cohen, A. I.: A possible cytological basis for the “R” membranes in the vertebrate eye. Nature (Lond.)205, 1222–1223 (1965).

    Google Scholar 

  • Duke-Elder, Sir Stewart: System of ophthalmology, vol. II. London: Kimpton 1961.

    Google Scholar 

  • Farquhar, M. G., Palade, G. E.: Junctional complexes in various epithelia. J. Cell Biol.17, 375–412 (1963).

    Article  CAS  PubMed  Google Scholar 

  • Fine, B. S.: Limiting membranes of the sensory retina and pigment epithelium Arch. Ophthal.66, 847–870 (1961).

    CAS  PubMed  Google Scholar 

  • —, Zimmerman, L. E.: Müllers cells and the “middle limiting membrane” of the human retina. Invest. Ophthal.1, 304–326 (1962).

    CAS  PubMed  Google Scholar 

  • ——: Observations on the rod and cone layer of the human retina. Invest. Ophthal.2, 446–459 (1963).

    CAS  PubMed  Google Scholar 

  • Greeff, R.: In: Graefe-Saemisch, Handbuch der gesamten Augenheilkunde 2. Aufl., Teil I, Bd. V. Leipzig: 1899.

  • Kaye, G. I., Pappas, G. D.: Studies on the cornea. I. The fine structure of the rabbit cornea and the uptake and transport of colloidal particles by the cornea in vivo. J. Cell Biol.12, 457–479 (1962).

    CAS  PubMed  Google Scholar 

  • ——, Donn, A., Mallet, N.: Studies on the cornea. II. The uptake of colloidal particles by the living rabbit cornea in vitro. J. Cell Biol.12, 481–501 (1962).

    CAS  PubMed  Google Scholar 

  • Leboucq, G.: Contribution a l'étude de la rétine chez les mammifères. Arch. Anat. micr. Morph. exp.5, 155 (1909).

    Google Scholar 

  • Miller, F.: Hemoglobin absorption by the cells of the proximal convoluted tubule in the mouse kidney. J. biophys. biochem. Cytol.8, 689 (1960).

    CAS  PubMed  Google Scholar 

  • Missotten, L.: Étude des Bâtonnets de la rétine humaine au microscope électronique. Ophthalmologica (Basel)140, 200–214 (1960).

    CAS  Google Scholar 

  • Missotten, L.: L'ultrasturcture des cônes de la rétine humaine. Bull. Soc. belge Ophtal.132, 472–502 (1963).

    Google Scholar 

  • —, Itterbeek, W. van: Étude de la rétine humaine au microscope électronique (note preliminaire). Bull. Soc. belge Ophtal.120, 608–617 (1959).

    Google Scholar 

  • Renard, G., Lemasson, C., Saraux, H.: Anatomie de l'oeil et de ses annexes, 1. Aufl. Paris: Masson 1965.

    Google Scholar 

  • Seefelder, R.: Die Entwicklung des menschlichen Auges. In: Kurzes Handbuch der Ophthalmologie. Hrsg.: F. Schiek, Bd. I. Berlin: Springer 1930.

    Google Scholar 

  • Sjöstrand, F. S.: The ultrasturcture of the inner segments of the retinal rods of the guinea pig eye as revealed by electron microscopy. J. cell. comp. Physiol.42, 45–70 (1953).

    Google Scholar 

  • Villegas, G. M.: Electron microscopic study of the vertebrate retina. J. gen. Physiol.43, (Suppl.), 15–43 (1960).

    PubMed  Google Scholar 

  • —: Ultrasturcture of the human retina. J. Anat. (Lond.)98, 501–513 (1964).

    CAS  Google Scholar 

  • Wald, F., De Robertis, E.: The action of glutamate and the problem of the “extracellular space” in the retina. Z. Zellforsch.55, 649–661 (1961).

    Article  CAS  PubMed  Google Scholar 

  • Wolff, E.: Anatomy of the eye and orbit, VI. Aufl. Philadelphia: Saunders 1968.

    Google Scholar 

  • Wolf-Heidegger, G.: Anatomie. In: Lehrbuch der Augenheilkunde, III. Aufl. Hrsg.: M. Amsler, A. Brückner, A. Franceschetti, H. Goldmann und E. B. Streiff. Basel: Karger 1961.

    Google Scholar 

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Authors and Affiliations

  1. Francis I. Proctor Foundation for Research in Ophthalmology, 94122, San Francisco, California, USA

    Manfred Spitznas

  2. Department of Ophthalmology, University of California, 94122, San Francisco, California, USA

    Manfred Spitznas

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  1. Manfred Spitznas
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Spitznas, M. Zur Feinstruktur der sog. Membrana limitans externa der menschlichen Retina. Albrecht von Graefes Arch. Klin. Ophthalmol. 180, 44–56 (1970). https://doi.org/10.1007/BF02384821

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  • DOI: https://doi.org/10.1007/BF02384821

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