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Taxuspine D, a new taxane diterpene fromTaxus cuspidata with potent inhibitory activity against Ca2+-induced depolymerization of microtubules

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Abstract

A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yewTaxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca2+-induced depolymerization of microtubules.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, 060, Sapporo

    J. Kobayashi, H. Hosoyama & H. Shigemori

  2. Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, 113, Tokyo, Japan

    Y. Koiso & S. Iwasaki

Authors
  1. J. Kobayashi
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  2. H. Hosoyama
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  3. H. Shigemori
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  4. Y. Koiso
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  5. S. Iwasaki
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Kobayashi, J., Hosoyama, H., Shigemori, H. et al. Taxuspine D, a new taxane diterpene fromTaxus cuspidata with potent inhibitory activity against Ca2+-induced depolymerization of microtubules. Experientia 51, 592–595 (1995). https://doi.org/10.1007/BF02128750

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  • DOI: https://doi.org/10.1007/BF02128750

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