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Effect of ergometrine on contractile force of guinea-pig isolated heart: Antagonism by cimetidine

  • Histamine and Kinins
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Abstract

The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.

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Authors and Affiliations

  1. Chair of Cardiovascular Diseases, University of Parma, Via Gramsci 14, Parma, Italy

    S. Bongrani, M. Di Donato & O. Visioli

  2. Institute of Pharmacology, University of Florence, Viale G.B. Morgagni 65, Italy

    P. Mantovani

Authors
  1. S. Bongrani
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  2. M. Di Donato
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  3. O. Visioli
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  4. P. Mantovani
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Bongrani, S., Di Donato, M., Visioli, O. et al. Effect of ergometrine on contractile force of guinea-pig isolated heart: Antagonism by cimetidine. Agents and Actions 9, 15–17 (1979). https://doi.org/10.1007/BF02024090

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  • DOI: https://doi.org/10.1007/BF02024090

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