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Atenolol, exaprolol and mast cell membranes

  • Histamine Release from Mast Cells and Basophils
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Abstract

Lipophilic exaprolol and hydrophilic atenolol differ in their interaction with mast cell membranes. Exaprolol, as compared with atenolol, significantly decreased32P incorporation into, but increased arachidonic acid liberation from, membrane phospholipids. Moreover, exaprolol significantly decreased phosphate incorporation in compound 48/80 and ConA-PS treated cells and decreased thromboxane formation in stimulated cells. On the other hand, atenolol decreased significantly only arachidonate liberation from stimulated mast cells. These results corroborate to some extent the effect of exaprolol and atenolol on histamine liberation which correlates with their membrane perturbing properties.

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References

  1. R. Nosál and Z. Menhyhardtová,The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiesterase on histamine release from isolated mast cells. Agents and Actions7, 231–236 (1977).

    PubMed  Google Scholar 

  2. C. G. Löfdahl,Selectivity of betaadrenoceptor agonists and antagonists in asthmatics. Eur. J. Respir. Dis.63 (Suppl. 120), 1–53 (1982).

    PubMed  Google Scholar 

  3. R. Nosál, K. Drábiková, J. Pecivová and K. Ondrias,Membrane perturbing activity of beta-adrenoceptor blocking drugs in isolated rat mast cells. Agents and Actions27, 36–38 (1989).

    PubMed  Google Scholar 

  4. J. Pecivová, K. Drábiková, V. Jancinová and R. Nosál,On the relationship between incorporation of 32 P into phospholipids and binding of beta-adrenoceptor blocking drugs to isolated mast cells. Agents 2and Actions23, 146–148 (1988).

    PubMed  Google Scholar 

  5. K. Drábiková, J. Pecivová, M. Petríková, V. Jancinová and R. Nosál,The effect of betaadrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A. Agents and Actions30, 77–80 (1990).

    PubMed  Google Scholar 

  6. A. Wada, S. Sakurai, M. Kobayashi, N. Yamagihara and F. Izumi,Suppression by phospholipase A 2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular uptake. Biochem. Pharmacol.32, 1175–1178 (1983).

    PubMed  Google Scholar 

  7. S. Nagai, S. Sugiyama and T. Okawa,Classification of beta-blocking agents by their inhibitory effects on phospholipase activity. Jap. Circ. J.50, 238–241 (1986).

    PubMed  Google Scholar 

  8. K.S. Authi, M. Lagarde and N. Crawford,Diacylglycerol lipase activity in human platelet intracellular and surface membranes. FEBS Lett.180, 95–101 (1985).

    PubMed  Google Scholar 

  9. J. Dachary-Prigent, J. Dufourcq, C. Lussan and M. Boisseau,Propranolol, chlorpromazine and platelet membrane: a fluorescence study of the drug-membrane interaction. Thromb. Res.14, 15–22 (1979).

    PubMed  Google Scholar 

  10. L. Herbette, A.M. Katz and J.M. Sturtevant,Comparison of the interaction of propranolol and timolol with model and biological membrane systems. Mol. Pharmacol.24, 259–269 (1983).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská 2, 84216, Bratislava, Czechoslovakia

    J. Pecivová, K. Drábiková, V. Jancinová, M. Petríková & R. Nosál

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  1. J. Pecivová
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  2. K. Drábiková
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  3. V. Jancinová
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  4. M. Petríková
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  5. R. Nosál
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Pecivová, J., Drábiková, K., Jancinová, V. et al. Atenolol, exaprolol and mast cell membranes. Agents and Actions 33, 41–43 (1991). https://doi.org/10.1007/BF01993122

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  • DOI: https://doi.org/10.1007/BF01993122

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