Abstract
The role of the platelet-neutrophil interaction in inflammation is discussed, as mediated by PAF released from neutrophils. Data fromin vivo andin vitro studies suggest that PAF is intimately involved in multiple interactions between neurophils and platelets.
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P.M. Henson andM.H. Ginsberg, Immunological reactions of platelets. InPlatelets in Biology and Pathology (Ed.J. Gordon) Elsevier/North-Holland Biomedical Press, Amsterdam 1981 (in press).
R.L. Nachman andM. Polley, The platelet as an inflammatory cell. InAdvances in Inflammation Research, vol. 1, p. 169 (EdsG. Weissman, B. Samuelson andR. Paoletti) Raven Press, New York 1979.
G.L. Larsen, K.M. McCarthy, R.O. Webster, J.E. Henson andP.M. Henson,A differential effect of C5a and C5a des Arg in the induction of pulmonary inflammation, Am. J. Pathol.100, 179 (1980).
J.O. Shaw, P.M. Henson, J.E. Henson andR.O. Webster,Lung inflammation induced by complement derived chemotactic fragments in the alveolus, Lab. Invest.42, 547 (1980).
T.C. Kravis andP.M. Henson,Accumulation of platelets at sites of antigen-antibody-mediated injury: A possible role for IgE antibody and mast cells, J. Immunol.118, 1569 (1977).
P.M. Henson andC.G. Cochrane,Immunological induction of increased vascular permeability. I. A rabbit passive cutaneous anaphylactic reaction requiring complement, platelets and neutrophils, J. Exp. Med.129, 153 (1969).
P. M. Henson andS.J. Betz, Neutrophil and platelet interactions in ‘allergic’ and inflammatory reactions: A role for acetyl glyceryl ether phosphorylcholine (platelet activating factor). InSecond International Symposium on the Biochemistry of the Acute Allergic Reaction (EdsK.F. Austen andE.L. Becker) Blackwell Scientific 1981 (in press).
P.M. Henson,Mechanisms of release of constituents from rabbit platelets by antigen-antibody complexes and complement. II. Interaction of platelets with neutrophils, J. Immunol.105, 490 (1970).
J. Benveniste, P.M. Henson andC.G. Cochrane,Leukocyte-dependent histamine release from rabbit platelets: The role of IgE, basophils and a platelet activating factor, J. Exp. Med.136, 1356 (1972).
J.M. Lynch, G.Z. Lotner, S.J. Betz andP.M. Henson,The release of a platelet activating factor by stimulated rabbit neutrophils, J. Immunol.123, 1219 (1979).
P.O. Clark, D.J. Hanahan andR.N. Pinckard,Physical and chemical properties of platelet activating factor (PAF) obtained from human neutrophils and monocytes and rabbit neutrophils and basophils, Biochem. Biophys. Acta628, 69 (1980).
G.Z. Lotner, J.M. Lynch andP.M. Henson,A platelet activating factor derived from human neutrophils, J. Immunol.124, 676 (1980).
S.J. Betz andP.M. Henson,Production and release of platelet activating factor (PAF): dissociation from degranulation and superoxide production in the human neutrophil, J. Immunol.125, 2756 (1980).
S.J. Betz, G.Z. Lotner andP.M. Henson,Generation and release of platelet activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF, J. Immunol.125, 2749 (1980).
M. Sanchez-Crespo, F. Alonso andJ. Egido,Platelet activating factor in anaphylaxis and phagocytosis. I. Release from human peripheral polymorphonuclears and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils, Immunology40, 645 (1980).
J.M. Mencia-Huerta andJ. Benveniste,Platelet activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes Eur. J. Immunol.9, 409 (1979).
R.N. Pinckard, M. Halonen, J.D. Palmer, C. Butler, J.O. Shaw andP.M. Henson,Intravascular aggregation and pulmonary sequestration of platelets during IgE-induced systemic anaphylaxis in the rabbit. Abrogation of lethal anaphylactic shock by platelet depletion, J. Immunol.119, 2185 (1977).
P.M. Henson,Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen, J. Exp. Med.131, 287 (1970).
L.M. McManus, D.J. Hanahan, C.A. Demopoulos andR.N. Pinckard,Pathobiology of intravenous infusion of acetyl glyceryl ether mediator (AGEM), a synthetic platelet activating factor (PAF), in the rabbit, J. Immunol. 1981 (in press).
M. Chignard, J.P. LeCouedic, M. Tence, B.B. Vargaftig andJ. Benveniste,The role of platelet activating factor in platelet aggregation, Nature279, 799 (1979).
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Henson, P.M. Platelet-activating factor (PAF) as a mediator of neutrophil-platelet interactions in inflammation. Agents and Actions 11, 545–547 (1981). https://doi.org/10.1007/BF01978732
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DOI: https://doi.org/10.1007/BF01978732