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Platelet Functions Beyond Hemostasis

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Molecular and Cellular Biology of Platelet Formation

Abstract

Platelets are small cellular fragments lacking a nucleus, derived from megakaryocytes, and are well known to have a major role in maintaining hemostasis. Apart from this well-established role, it is now becoming evident that platelets also have other important functions, besides hemostasis, during infection and inflammation. This chapter will focus on these nonhemostatic functions of platelets, in general, outlined as “platelets versus pathogens” and “platelet-target cell communication.” Platelets actively contribute to protection against invading pathogens and are capable of regulating immune functions in various target cells, all through an array of sophisticated mechanisms. These relatively novel features will be discussed, demonstrating an important multifunctional role of platelets in an inflammatory setting.

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Authors and Affiliations

  1. Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada

    Rick Kapur & John W. Semple

  2. Canadian Blood Services, St. Michael’s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada

    Rick Kapur & John W. Semple

  3. Departments of Pharmacology, University of Toronto, Toronto, ON, Canada

    John W. Semple

  4. Departments of Medicine, University of Toronto, Toronto, ON, Canada

    John W. Semple

  5. Departments of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    John W. Semple

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  1. Rick Kapur
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Correspondence to John W. Semple .

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Editors and Affiliations

  1. Institute of Experimental Biomedicine I, University Hospital Würzburg, Würzburg, Germany

    Harald Schulze

  2. Vascular Biology Programm, Harvard Medical School, Boston, Massachusetts, USA

    Joseph Italiano

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Kapur, R., Semple, J.W. (2016). Platelet Functions Beyond Hemostasis. In: Schulze, H., Italiano, J. (eds) Molecular and Cellular Biology of Platelet Formation. Springer, Cham. https://doi.org/10.1007/978-3-319-39562-3_10

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