Summary
Methylene blue was found to inhibit thiamine transport competitively (Ki=0.63 μM) in baker's yeast. The dye was also effective in abolishing the growth inhibition ofSaccharomyces cerevisiae by pyrithiamine which is known to be taken up by a common transport system for thiamine in yeast cells. A possible mechanism for the inhibition by methylene blue of the thiamine transport system in baker's yeast is discussed.
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Iwashima, A., Nishimura, H. & Nishino, H. Inhibition of thiamine transport in baker's yeast by methylene blue. Experientia 36, 1153–1154 (1980). https://doi.org/10.1007/BF01976094
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DOI: https://doi.org/10.1007/BF01976094