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Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity

  • Immunosuppression and Inflammation
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Abstract

In the present study, the effects of acetylsalicylic acid, diclofenac, ibuprofen, indomethacin, naproxen, phenylbutazone, proquazone, fluproquazone (RF 46-790 N), sulindac (sulfoxide and sulfide forms) and tolfenamic acid were compared on rat gastric mucosal cyclic nucleotide phosphodiesterases (PDEs).

Some of the drugs inhibited PDEs effectively, theK i values being clearly lower than those of theophylline. Mostly the type of inhibition was apparently competitive. Acetylsalicylic acid and ibuprofen were ineffective. No unambiguous correlation between the inhibition of mucosal PDEs and clinically observed gastric irritation was found. However, the inhibition of PDEs may modulate gastric sideeffects of NSAIDs.

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Tampere, Box 607, SF-33101, Tampere 10, Finland

    J. Silvola, M. Kangasaho, O. Tokola & H. Vapaatalo

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  1. J. Silvola
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  2. M. Kangasaho
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  3. O. Tokola
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  4. H. Vapaatalo
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Silvola, J., Kangasaho, M., Tokola, O. et al. Effects of nonsteroidal anti-inflammatory drugs on rat gastric mucosal phosphodiesterase activity. Agents and Actions 12, 516–520 (1982). https://doi.org/10.1007/BF01965936

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  • DOI: https://doi.org/10.1007/BF01965936

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