Summary
5-Hydroxytryptamine (5-HT) administered intraventricularly (i.vent.) in rats produced hypertension without considerable changes in heart rate. After transsection of the spinal cord or i.vent. administration of methysergide, 5-HT failed to produce the pressor effect. Thus, the hypertension results from the activation of 5-HT receptor sites of the rat brain.
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This work was supported by Union of Scientific Medical Institutions of Serbia (Grant No. 85).
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Krstić, M.K., Djurković, D. Hypertension mediated by the activation of the rat brain 5-hydroxytryptamine receptor sites. Experientia 32, 1187–1189 (1976). https://doi.org/10.1007/BF01927618
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DOI: https://doi.org/10.1007/BF01927618