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Role of 5-HT2B Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart

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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of α-methyl-5-hydroxytryptamine maleate, an agonist of 5-HT2B serotonin receptors, on the pumping function of the heart was examined in rats with forced motor behavior. At rest, swim-trained rats demonstrated lower HR and greater stroke volume and cardiac output than untrained rats. The agonist decreased HR, stroke volume, and cardiac output in 21- and 70-day-old swim-trained rats, but not in 100- and 200-day-old rats

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Authors and Affiliations

  1. Kazan Federal University, Kazan, Russia

    R. A. Abzalov, A. M. Valeev, N. I. Abzalov & A. A. Gulyakov

Authors
  1. R. A. Abzalov
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  2. A. M. Valeev
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  3. N. I. Abzalov
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  4. A. A. Gulyakov
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Correspondence to R. A. Abzalov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 278-280, March, 2015

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Abzalov, R.A., Valeev, A.M., Abzalov, N.I. et al. Role of 5-HT2B Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart. Bull Exp Biol Med 159, 302–304 (2015). https://doi.org/10.1007/s10517-015-2947-0

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  • DOI: https://doi.org/10.1007/s10517-015-2947-0

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