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Evaluation of the susceptibility of pathogenicCandida species to fluconazole

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Abstract

A fluconazole 25 ug disk diffusion test was used to test 2230 consecutively isolatedCandida strains from 42 different hospital laboratories in 23 countries. Ninety seven percent of 1634Candida albicans isolates and 83.4% of 596 non-Candida albicans isolates were susceptible to fluconazole, applying the proposed breakpoints (≥26 mm for susceptible strains and 18–25 mm for dosedependent susceptible strains). This is the first hospital laboratory study to evaluate a large number and wide range of sequentialCandida isolates from patients with all types of hospital infections. The fluconazole disk diffusion test appears to be a low-cost, reproducible, and accurate means of assessing the in vitro susceptibility ofCandida isolates.

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Authors and Affiliations

  1. Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, CH-1011, Lausanne, Switzerland

    J. Bille

  2. Division of Infectious Disease, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 44, CH-1011, Lausanne, Switzerland

    M. P. Glauser

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  1. J. Bille
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  2. M. P. Glauser
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Fluconazole Global Susceptibility Study Group

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Bille, J., Glauser, M.P. & Fluconazole Global Susceptibility Study Group. Evaluation of the susceptibility of pathogenicCandida species to fluconazole. Eur. J. Clin. Microbiol. Infect. Dis. 16, 924–928 (1997). https://doi.org/10.1007/BF01700561

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