Summary
Saccharomyces cerevisiae grown under different hypoxic conditions (oxygen deprivation, high hexose concentrations and inhibition of the mitochondrial synthesis of proteins) accumulates significant amounts of succinic acid as an end product. Similar results have been obtained with the impaired respiration mutant.
The succinate accumulation supports the postulated reductive function of a branch of the tricarboxylic acid cycle leading from oxalacetate to succinate in hypoxia.
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Lupiañez, J.A., Machado, A., Nuñez de Castro, I. et al. Succinic acid production by yeasts grown under different hypoxic conditions. Mol Cell Biochem 3, 113–116 (1974). https://doi.org/10.1007/BF01659183
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DOI: https://doi.org/10.1007/BF01659183