Summary
Cefadroxil is a new semisynthetic cephalosporin with a broad antibacterial spectrum and a high chemotherapeutic potential when administered orally. The inhibitory activity of this compound was similar to that of cephalexin and cephradine when tested against 602 clinical isolates on Mueller-Hinton medium. In the oral treatment of experimental infections of mice, cefadroxil was more effective than cephalexin againstStreptococcus pyogenes, and comparably effective againstStreptococcus pneumoniae, Staphylococcus aureus, and several gram-negative species. Administered orally to mice, at doses ranging from 25 to 100 mg/kg, cefadroxil attained peak concentrations in the blood similar to those of cephalexin. At a dose of 200 mg/kg, however, higher peak levels were noted with cefadroxil than with cephalexin. In regard to other properties which were investigated, the behavior of cefadroxil compared favorably to that of cephalexin.
Zusammenfassung
Cefadroxil ist ein neues halbsynthetisches Cephalosporin mit breitem antibakteriellem Spektrum und einer hohen chemotherapeutischen Wirksamkeit bei oraler Anwendung. Bei Testung von 602 klinischen Isolaten auf Mueller-Hinton Medium war die inhibitorische Aktivität dieser Verbindung ähnlich wie die von Cephalexin und Cephradin. Bei der oralen Behandlung von experimentellen Infektionen in Mäusen war Cefadroxil gegenStreptococcus pyogenes wirksamer als Cephalexin und von vergleichbarer Effektivität gegenüberStreptococcus pneumoniae, Staphylococcus aureus und verschiedene gramnegative Spezies. Cefadroxil erreichte nach oraler Anwendung bei Mäusen in Dosen von 25 bis 100 mg/kg ähnliche Serumspitzenkonzentrationen wie Cephalexin. Mit einer Dosis von 200 mg/kg wurden hingegen mit Cefadroxil höhere maximale Serumkonzentrationen festgestellt als mit Cephalexin. In den anderen überprüften Eigenschaften zeigte Cefadroxil Vorzüge gegenüber Cephalexin.
Similar content being viewed by others
Literature
Clark, H., Turck, M.: In vitro and in vivo evaluation of cephalexin. Antimicrob. Agents Chemother. (1969) 296–301.
Kind, A. C., Kestle, D. G., Standiford, H. C., Kirby, W. M. M.: Laboratory and clinical experience with cephalexin. Antimicrob. Agents Chemother. (1969) 361–365.
Perret, C. J. Iodometric assay of penicillinase. Nature (London) 174 (1954) 1012–1013.
Pfeffer, M., Jackson, A., Ximenes, J., de Menezes, J. P. Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine. Antimicrob. Ag. Chemother. 11 (1977) 331–338.
Price, K. E., Bach, J. A., Chisholm, D. R., Misiek, M., Gourevitch, A. Preliminary microbiological and pharmacological evaluation of 6-(R-α-amino-3-thienylacetamido)penicillanic acid (BL-P875). J. Antibiot. (Tokyo) 22 (1969) 1–11.
Richmond, M. H., Sykes, R. B. The β-lactamases of gram-negative bacteria and their possible physiological role. Adv. Microb. Physiol. 9 (1973) 31–88.
Steers, E., Foltz, F. L., Graves, B. S. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. Antibiot. Chemother. 9 (1959) 307–311.
Stewart, D., Bodey, G. P. Comparative in vitro activity of cephalosporins. J. Antibiot. 29 (1976) 181–186.
Wick, W. E. Cephalexin, a new orally absorbed cephalosporin antibiotic. Appl. Microbiol. 15 (1967) 765–769.
Author information
Authors and Affiliations
Additional information
Erstveröffentlichung: Antimicrob. Agents Chemother. 11 (1977) 324.
Rights and permissions
About this article
Cite this article
Buck, R.E., Price, K.E. Cefadroxil, a new broad-spectrum cephalosporin. Infection 8 (Suppl 5), S532–S537 (1980). https://doi.org/10.1007/BF01639665
Issue Date:
DOI: https://doi.org/10.1007/BF01639665