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Habituation in the crabChasmagnathus granulatus: effect of morphine and naloxone

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Summary

The escape response decrement shown by the crabChasmagnathus granulatus as a consequence of repeated shadow presentation, meets five of the seven tested parametric criteria of habituation. Results concerning stimulus generalization and dishabituation strongly suggest that neither motor fatigue nor sensory adaptation can account for the response waning. The effects of morphine and naloxone on performance were also studied. Neither 50 nor 5 μg morphine/g exerted any modulatory effect on memory retention. A dose of 50 μg morphine/g produced an anterograde detrimental effect on responsiveness but no long-term training effects could be detected after the drug's period of action. A dose of naloxone of 1.6 μg/g did not antagonize the effect of morphine. The potential value of the response habituation as a model for studying both habituation dynamics and the mechanisms that subserve it, and also for elucidating the effects of opiates on this memory process, is discussed.

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Abbreviations

ANOVA :

analysis of variance

d.w. :

distilled water

ITI :

intertriai interval

LOR :

large opaque rectangle

M P :

morphine-HCl

NX :

naloxone

S1 :

first trial session

S2 :

second trial session

S3 :

third trial session

S4 :

fourth trial session

S5 :

fifth trial session

SOR :

small opaque rectangle

STR :

small translucent rectangle

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Authors and Affiliations

  1. Facultad de Ciencias Exactas y Naturales, Laboratorio de Fisiologia del Comportamiento Animal, USA

    Daniela Brunner & Hector Maldonado

  2. Avda Indalecio Chenaut 1910, 1426, Buenos Aires, Argentina

    Daniela Brunner & Hector Maldonado

Authors
  1. Daniela Brunner
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  2. Hector Maldonado
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Brunner, D., Maldonado, H. Habituation in the crabChasmagnathus granulatus: effect of morphine and naloxone. J. Comp. Physiol. 162, 687–694 (1988). https://doi.org/10.1007/BF01342643

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  • DOI: https://doi.org/10.1007/BF01342643

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