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Dopamine agonists prevent duodenal ulcer relapse

A comparative study with famotidine and cimetidine

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Abstract

The present study investigated both the healing rate (after four weeks) and the relapse rate (during six months) following treatment with the dopamine-like drugs bromocriptine (2.5 mg twice daily), amantadine (100 mg nocte), or with the H2 blockers cimetidine (800 mg nocte), and famotidine (40 mg nocte) in 124 patients with endoscopically proven duodenal ulcer (DU). The ulcer was completely healed in 27 (amantadine), 26 (bromocriptine), 23 (cimetidine), and in 24 (famotidine) patients. Relapse was noted in 34.7% (cimetidine) and 25% (famotidine) versus 11.7% (amantadine) and 7.7% (bromocriptine) DU patients. No significant difference was found in initial healing rates. However, the relapse rate in the cimetidine-treated group was significantly higher than in all the other test groups. Additional comparisons between all the treatment categories showed a significantly lower relapse rate with the dopamine-like agents. These important new results indicate that dopamine-like compounds are equally effective as H2 blockers in inducing DU healing and may offer a promising advantage over H2 blockers concerning their efficacy in preventing ulcer relapse in DU patients.

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Authors and Affiliations

  1. Department of Pharmacology, Pathology and Endocrinology, Medical Faculty and Veterinary Faculty University of Zagreb, Zagreb

    Predrag Sikiric MD, PhD, Ivo Rotkvic MD, PhD, Stephan Mise PhD, Marijan Petek PhD, Rudolf Rucman PhD, Sven Seiwerth MD, Vanja Zjacic-Rotkvic PhD, Marko Duvnjak PhD, Vjekoslav Jagic PhD, Ernest Suchanek PhD, Zeljko Grabarevic DVM, Tomislav Anic PhD, Tomislav Brkic MD, Zoran Djermanovic MD, Milan Dodig MD, Anton Marovic MD & Daniel E. Hernandez DVM

  2. Department of Gastroenterology, Surgery, Endocrinology and Biochemistry Clinical Hospital “Dr. M. Stojanovic”, University Hospital “Zagreb” and General Hospital “Dr. J. Kajfes”, Zagreb

    Predrag Sikiric MD, PhD, Ivo Rotkvic MD, PhD, Stephan Mise PhD, Marijan Petek PhD, Rudolf Rucman PhD, Sven Seiwerth MD, Vanja Zjacic-Rotkvic PhD, Marko Duvnjak PhD, Vjekoslav Jagic PhD, Ernest Suchanek PhD, Zeljko Grabarevic DVM, Tomislav Anic PhD, Tomislav Brkic MD, Zoran Djermanovic MD, Milan Dodig MD, Anton Marovic MD & Daniel E. Hernandez DVM

  3. Clinical Hospital “Firule” Split, and Research Institute “Lek”, Ljubljana, Yugoslavia

    Predrag Sikiric MD, PhD, Ivo Rotkvic MD, PhD, Stephan Mise PhD, Marijan Petek PhD, Rudolf Rucman PhD, Sven Seiwerth MD, Vanja Zjacic-Rotkvic PhD, Marko Duvnjak PhD, Vjekoslav Jagic PhD, Ernest Suchanek PhD, Zeljko Grabarevic DVM, Tomislav Anic PhD, Tomislav Brkic MD, Zoran Djermanovic MD, Milan Dodig MD, Anton Marovic MD & Daniel E. Hernandez DVM

  4. Division of Gastrointestinal and Liver Diseases Division, University of Southern California School of Medicine, 90033, Los Angeles, California

    Predrag Sikiric MD, PhD, Ivo Rotkvic MD, PhD, Stephan Mise PhD, Marijan Petek PhD, Rudolf Rucman PhD, Sven Seiwerth MD, Vanja Zjacic-Rotkvic PhD, Marko Duvnjak PhD, Vjekoslav Jagic PhD, Ernest Suchanek PhD, Zeljko Grabarevic DVM, Tomislav Anic PhD, Tomislav Brkic MD, Zoran Djermanovic MD, Milan Dodig MD, Anton Marovic MD & Daniel E. Hernandez DVM

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  1. Predrag Sikiric MD, PhD
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  2. Ivo Rotkvic MD, PhD
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  9. Vjekoslav Jagic PhD
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  10. Ernest Suchanek PhD
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  11. Zeljko Grabarevic DVM
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  15. Milan Dodig MD
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Sikiric, P., Rotkvic, I., Mise, S. et al. Dopamine agonists prevent duodenal ulcer relapse. Digest Dis Sci 36, 905–910 (1991). https://doi.org/10.1007/BF01297139

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  • DOI: https://doi.org/10.1007/BF01297139

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