Summary
Enhancement of interferon production in mouse peritoneal macrophages by Newcastle disease virus (NDV) under-neutralized with whole antiserum or its IgG fraction was inhibited in cells pretreated with iodoacetamide, sodium nitrite or formaldehyde, which blocked adsorption of cytophilic antibody to macrophages. Mouse embryo primary culture cells had no receptor for cytophilic antibody, and in such a cell culture, under-neutralized NDV did not enhance interferon production. Antiserum enhanced interferon production by NDV which had adsorbed to cell surfaces, but did not affect NDV that had penetrated the cells.
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Azuma, M. Participation of cytophilic antibody in enhancement of interferon production in macrophages by under-neutralized NDV. Archiv f Virusforschung 41, 11–19 (1973). https://doi.org/10.1007/BF01249924
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DOI: https://doi.org/10.1007/BF01249924