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Immunochemical activity of the Yersinia pseudotuberculosis B-antigen

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Abstract

A hybridoma panel producing monoclonal antibodies to immunochemically nonidentical anti-genic epitopes of a protein nature located in the outer membrane of Yersinia pseudotuberculosis was obtained. It was revealed that the previously identified B-antigen that protects laboratory animals from experimental plague being used for active immunization was detected using monoclonal antibodies both against the men-tioned protein determinants and determinants of lipopolysaccharide O-side chains. B-antigen is a compo-nent of the Y. pseudotuberculosis outer membrane, which is egested in the form of vesicles (OMVs) by bacteria cultivated in a fluid nutrient medium.

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Authors and Affiliations

  1. Vyatka State University, Kirov, 610000, Russia

    A. A. Byvalov, L. G. Dudina, A. V. Chernyad’ev, I. V. Konyshev & S. G. Litvinets

  2. Institute of Physiology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, 167982, Russia

    A. A. Byvalov, L. G. Dudina, I. V. Konyshev & Yu. S. Ovodov

Authors
  1. A. A. Byvalov
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  2. L. G. Dudina
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  3. A. V. Chernyad’ev
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  4. I. V. Konyshev
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  5. S. G. Litvinets
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  6. Yu. S. Ovodov
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Corresponding author

Correspondence to A. A. Byvalov.

Additional information

Original Russian Text © A.A. Byvalov, L.G. Dudina, A.V. Chernyad’ev, I.V. Konyshev, S.G. Litvinets, Yu.S. Ovodov, 2015, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2015, No. 2, pp. 32–38.

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Byvalov, A.A., Dudina, L.G., Chernyad’ev, A.V. et al. Immunochemical activity of the Yersinia pseudotuberculosis B-antigen. Mol. Genet. Microbiol. Virol. 30, 93–100 (2015). https://doi.org/10.3103/S0891416815020032

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  • DOI: https://doi.org/10.3103/S0891416815020032

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